2-{[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetyl}-N-(4-fluorophenyl)hydrazinecarbothioamide

Base Information

• Chemical Name: 2-{[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetyl}-N-(4-fluorophenyl)hydrazinecarbothioamide
• CAS No.: 1257409-52-1
• Molecular Formula: C₂₉H₂₆ClFN₈O₃S
• Molecular Weight: 621.095

Synonyms:

Chemical Property of 2-{[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetyl}-N-(4-fluorophenyl)hydrazinecarbothioamide

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Technology Process of 2-{[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetyl}-N-(4-fluorophenyl)hydrazinecarbothioamide

There total 1 articles about 2-{[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetyl}-N-(4-fluorophenyl)hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetohydrazide (1257409-46-3) + 4-fluorophenyl isothiocyanate (1544-68-9) → 2-{[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetyl}-N-(4-fluorophenyl)hydrazinecarbothioamide (1257409-52-1)

Guidance literature:

In ethanol; for 4h; Reflux;

DOI:10.1016/j.ejmech.2010.07.018

Reference yield: 77.0%

2-{[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetyl}-N-(4-fluorophenyl)hydrazinecarbothioamide (1257409-52-1) → 4-(2-phenyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-5-(4-chlorobenzyl)-2-{[4-(4-fluorophenyl)-5-mercapto-4H-1,2,4-triazol-3-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one (1257409-64-5)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 3h; Reflux;

DOI:10.1016/j.ejmech.2010.07.018

Reference yield: 59.0%

2-{[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetyl}-N-(4-fluorophenyl)hydrazinecarbothioamide (1257409-52-1) → 4-(2-phenyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-yl)-5-(4-chlorobenzyl)-2-{[5-(4-fluorophenylamino)-1,3,4-thiadiazol-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-one (1257409-61-2)

Guidance literature:

With sulfuric acid; at 20 ℃; Cooling with ice;

DOI:10.1016/j.ejmech.2010.07.018

upstream raw materials:

2-[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-yl]acetohydrazide

4-fluorophenyl isothiocyanate

Downstream raw materials:

4-(2-phenyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-yl)-5-(4-chlorobenzyl)-2-{[5-(4-fluorophenylamino)-1,3,4-thiadiazol-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-one

4-(2-phenyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-5-(4-chlorobenzyl)-2-{[4-(4-fluorophenyl)-5-mercapto-4H-1,2,4-triazol-3-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one

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