1-(1-Naphthyl)cyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-(1-Naphthyl)cyclopropanecarboxylic acid
• CAS No.: 124276-38-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.248
• DSSTox Substance ID: DTXSID701253548
• Mol file: 124276-38-6.mol

Synonyms:1-(1-Naphthyl)cyclopropanecarboxylic acid;124276-38-6;1-naphthalen-1-ylcyclopropane-1-carboxylic acid;MFCD11037019;SCHEMBL697151;OUJODVKEBCXFEI-UHFFFAOYSA-N;DTXSID701253548;AC3333;AKOS016401703;AB90124;1-(1-Naphthyl)cyclopropanecarboxylicAcid;AS-79285;SY225777;1-(1-Naphthyl)cyclopropane carboxylic acid;CS-0196616;1-(1-Naphthalenyl)cyclopropanecarboxylic acid;EN300-1847627;A920467;1-(NAPHTHALEN-1-YL)CYCLOPROPANE-1-CARBOXYLIC ACID

Chemical Property of 1-(1-Naphthyl)cyclopropanecarboxylic acid

Chemical Property:

• Vapor Pressure: 1.2E-07mmHg at 25°C
• Melting Point: 187-189 °C
• Boiling Point: 415.5±24.0 °C(Predicted)
• PKA: 4.78±0.20(Predicted)
• Density: 1.308±0.06 g/cm3(Predicted)
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 293

Purity/Quality:

97% ^*data from raw suppliers

1-(NAPHTHALEN-1-YL)CYCLOPROPANECARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1(C2=CC=CC3=CC=CC=C32)C(=O)O

Technology Process of 1-(1-Naphthyl)cyclopropanecarboxylic acid

There total 4 articles about 1-(1-Naphthyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aqueous potassium hydroxide + 1-(naphthalen-1-yl)cyclopropanecarbonitrile (56477-59-9) → 1-[1]naphthyl-cyclopropanecarboxylic acid (124276-38-6)

Guidance literature:

With hydrogenchloride; In water; ethylene glycol;

Reference yield:

→ 1-[1]naphthyl-cyclopropanecarboxylic acid (124276-38-6)

Guidance literature:

With sulfuric acid; acetic acid;

DOI:10.1021/ja01224a007

Reference yield:

naphthalen-1-ylacetonitrile (132-75-2) → 1-[1]naphthyl-cyclopropanecarboxylic acid (124276-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 18 h

2.1: lithium hydroxide / water / 18 h / Reflux

With sodium hydride; lithium hydroxide; In water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/adsc.201800886

upstream raw materials:

1-(naphthalen-1-yl)cyclopropanecarbonitrile

naphthalen-1-ylacetonitrile