1-naphthalen-1-ylcyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-naphthalen-1-ylcyclopropanecarboxylic acid
• CAS No.: 124276-38-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.248
• Mol file: 124276-38-6.mol

Synonyms:

Chemical Property of 1-naphthalen-1-ylcyclopropanecarboxylic acid

Chemical Property:

• Vapor Pressure: 1.2E-07mmHg at 25°C
• Melting Point: 187-189 °C
• Boiling Point: 415.5±24.0 °C(Predicted)
• PKA: 4.78±0.20(Predicted)
• Density: 1.308±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

1-(NAPHTHALEN-1-YL)CYCLOPROPANECARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-naphthalen-1-ylcyclopropanecarboxylic acid

There total 4 articles about 1-naphthalen-1-ylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aqueous potassium hydroxide + 1-(naphthalen-1-yl)cyclopropanecarbonitrile (56477-59-9) → 1-[1]naphthyl-cyclopropanecarboxylic acid (124276-38-6)

Guidance literature:

With hydrogenchloride; In water; ethylene glycol;

Reference yield:

→ 1-[1]naphthyl-cyclopropanecarboxylic acid (124276-38-6)

Guidance literature:

With sulfuric acid; acetic acid;

DOI:10.1021/ja01224a007

Reference yield:

naphthalen-1-ylacetonitrile (132-75-2) → 1-[1]naphthyl-cyclopropanecarboxylic acid (124276-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 18 h

2.1: lithium hydroxide / water / 18 h / Reflux

With sodium hydride; lithium hydroxide; In water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/adsc.201800886

upstream raw materials:

1-(naphthalen-1-yl)cyclopropanecarbonitrile

naphthalen-1-ylacetonitrile

Refernces

• 1、 -. "Tetraisoquinoline compounds which have useful pharmaceutical utility". . . Retrieved 2008/06/13.