2,6-Dibromopyridin-4-ol

Base Information

• Chemical Name: 2,6-Dibromopyridin-4-ol
• CAS No.: 220616-68-2
• Molecular Formula: C₅H₃Br₂NO
• Molecular Weight: 252.893
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50702663
• Nikkaji Number: J2.860.183B
• Wikidata: Q72464989
• Mol file: 220616-68-2.mol

Synonyms:2,6-Dibromopyridin-4-ol;220616-68-2;2,6-Dibromo-4-hydroxypyridine;2,6-dibromo-1H-pyridin-4-one;2,6-Dibromo-4-pyridinol;MFCD13185517;4-Pyridinol, 2,6-dibromo-;SCHEMBL22321658;2,6-Dibromopyridin-4(1H)-one;DTXSID50702663;VIA61668;AKOS016012800;DS-5339;SB52227;SY117464;CS-0092859;FT-0753260;C74116;AR-362/43519191

Chemical Property of 2,6-Dibromopyridin-4-ol

Chemical Property:

• Boiling Point: 461.8 °C at 760 mmHg
• PKA: 6.29±0.23(Predicted)
• Flash Point: 233.1 °C
• PSA: 33.12000
• Density: 2.228 g/cm³
• LogP: 2.31220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 252.85609
• Heavy Atom Count: 9
• Complexity: 187

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dibromo-4-hydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(NC(=CC1=O)Br)Br

Technology Process of 2,6-Dibromopyridin-4-ol

There total 7 articles about 2,6-Dibromopyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,6-Dibromopyridine (626-05-1) → 2,6-dibromo-4-hydroxypyridine (220616-68-2,253435-45-9)

Guidance literature:

With pinacol borane; 1,2-bis-(diphenylphosphino)ethane; chloro(1,5-cyclooctadiene)iridium(I) dimer; at 130 ℃; for 4h;

DOI:10.1002/chem.200600315

Reference yield: 90.0%

4-allyloxy-2,6-dibromopyridine (220616-67-1) → 2,6-dibromo-4-hydroxypyridine (220616-68-2,253435-45-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; Wilkinson's catalyst; In ethanol; water; acetonitrile; at 70 ℃; for 6h;

DOI:10.1021/ja983539u

Reference yield:

2,6-dibromo-4-nitropyridine (175422-04-5) → 2,6-dibromo-4-hydroxypyridine (220616-68-2,253435-45-9)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 72h;

DOI:10.1016/j.tet.2008.05.049

upstream raw materials:

4-allyloxy-2,6-dibromopyridine

2,6-Dibromopyridine

4-allyloxypyridine-2,6-dicarboxylic acid

2,6-dibromo-4-nitropyridine

Downstream raw materials:

2,6-bis(phenylethynyl)pyridin-4(1H)-one