2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid

Base Information

Chemical Name:2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid
CAS No.:80354-00-3
Molecular Formula:C₆H₃BrN₂O₂S
Molecular Weight:247.072
Hs Code.:2934100090
DSSTox Substance ID:DTXSID80508716
Wikidata:Q72457163
Mol file:80354-00-3.mol

Synonyms:2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid;80354-00-3;2-Bromoimidazo[2,1-b][1,3]thiazole-6-carboxylic acid;C6H3BrN2O2S;SCHEMBL1999180;DTXSID80508716;ZZARZXAKQBCCBX-UHFFFAOYSA-N;AMY27317;MFCD11841137;AKOS016012432;DS-5346;2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid;EN300-1602027;A864704;Z1269157908;2-Bromoimidazo[2 pound not1-b]thiazole-6-carboxylic acid;2-Bromoimidazo[2,1-b][1,3]thiazole-6-carboxylic acid, AldrichCPR

Suppliers and Price of 2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid 98%
100mg
$ 118.00

Crysdot
2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid 98%
250mg
$ 188.00

Crysdot
2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid 98%
1g
$ 469.00

Chemenu
2-bromoimidazo[2,1-b]thiazole-6-carboxylicacid 95+%
1g
$ 851.00

Chemenu
2-bromoimidazo[2,1-b]thiazole-6-carboxylicacid 95+%
250mg
$ 341.00

Chemenu
2-bromoimidazo[2,1-b]thiazole-6-carboxylicacid 95+%
100mg
$ 214.00

Ambeed
2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid 97%
100mg
$ 153.00

Ambeed
2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid 97%
250mg
$ 249.00

Ambeed
2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid 97%
1g
$ 586.00

Alichem
2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid
1g
$ 469.26

Total 11 raw suppliers

Chemical Property of 2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid

Chemical Property:

Melting Point:>300℃ (ethanol water )
PSA：82.84000
LogP:1.85650
Storage Temp.:2-8°C
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:245.90986
Heavy Atom Count:12
Complexity:216

Purity/Quality:

97% ^*data from raw suppliers

2-Bromoimidazo[2,1-b]thiazole-6-carboxylicacid 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(N=C2N1C=C(S2)Br)C(=O)O

Technology Process of 2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid

There total 2 articles about 2-Bromoimidazo[2,1-b]thiazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 80353-98-6
ethyl 2-bromoimidazo<2,1-b>thiazole-6-carboxylate

: 80354-00-3
2-bromoimidazo<2,1-b>thiazole-6-carboxylic acid

Guidance literature:: With hydrogenchloride; for 12h; Heating;

Reference yield:

: 80354-00-3
2-bromoimidazo<2,1-b>thiazole-6-carboxylic acid

Guidance literature:: With boron tribromide; In dichloromethane; at -10 - 25 ℃;

Reference yield:

: 80354-00-3
2-bromoimidazo<2,1-b>thiazole-6-carboxylic acid

: (S,R)-{2-oxo-1-phenyl-2-[2-(2-phenylethynylimidazo[2,1-b]thiazol-6-ylcarbamoyl)pyrrolidin-1-yl]ethyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / acetone / 3 h / 85 °C

1.2: 0.75 h / 0 - 10 °C

2.1: toluene; tert-butyl alcohol / 0.75 h / 100 °C / Microwave irradiation

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

4.1: HATU; triethylamine / N,N-dimethyl-formamide / 4 h / 40 °C

5.1: N,N,N',N'-tetramethylguanidine; copper(l) iodide; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / N,N-dimethyl-formamide / 0.5 h / 80 °C / Microwave irradiation

With hydrogenchloride; copper(l) iodide; thionyl chloride; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); triethylamine; HATU; N,N,N',N'-tetramethylguanidine; In 1,4-dioxane; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;