Technology Process of (1’S,3’S,7’R,8a’R)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]-3’-carboselenoate
There total 7 articles about (1’S,3’S,7’R,8a’R)-7’-(methoxycarbonylmethyl)-5’-oxo-1-(phenylsulfonyl)spiro[indoline-3,1’-indolizidine]-3’-carboselenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylsilane; titanium tetrachloride / dichloromethane / Inert atmosphere; Reflux
2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C
3: sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile; tert-butyl alcohol / 20 °C
4: tributylphosphine / dichloromethane / 16 h / Reflux
With
triethylsilane; sodium chlorite; sodium dihydrogenphosphate; tributylphosphine; titanium tetrachloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dichloromethane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c2cc38540f
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydroxide; tetrabutyl-ammonium chloride / water; dichloromethane / 0 - 20 °C
2: triethylsilane; titanium tetrachloride / dichloromethane / Inert atmosphere; Reflux
3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C
4: sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile; tert-butyl alcohol / 20 °C
5: tributylphosphine / dichloromethane / 16 h / Reflux
With
triethylsilane; sodium chlorite; sodium dihydrogenphosphate; tributylphosphine; tetrabutyl-ammonium chloride; titanium tetrachloride; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dichloromethane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c2cc38540f
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene / 24 h / Dean-Stark; Reflux
2: sodium hydroxide; tetrabutyl-ammonium chloride / water; dichloromethane / 0 - 20 °C
3: triethylsilane; titanium tetrachloride / dichloromethane / Inert atmosphere; Reflux
4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 h / 20 °C
5: sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile; tert-butyl alcohol / 20 °C
6: tributylphosphine / dichloromethane / 16 h / Reflux
With
triethylsilane; sodium chlorite; sodium dihydrogenphosphate; tributylphosphine; tetrabutyl-ammonium chloride; titanium tetrachloride; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c2cc38540f
![(3S,7R,8aS)-7-(methoxycarbonylmethyl)-5-oxo-3-[1-(phenylsulfonyl)-3-indolylmethyl]-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine](/Databaselist/images/loading.webp)
