Isoindolin-5-amine hydrochloride

Base Information

• Chemical Name: Isoindolin-5-amine hydrochloride
• CAS No.: 503614-81-1
• Molecular Formula: C8H11ClN2
• Molecular Weight: 170.642
• Hs Code.: 2933990090
• Mol file: 503614-81-1.mol

Synonyms:1H-isoindol-5-amine, 2,3-dihydro-, hydrochloride (1:1);2,3-dihydro-1H-isoindol-5-amine hydrochloride (1:1);Isoindolin-5-amine hydrochloride (1:1);

Chemical Property of Isoindolin-5-amine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00026mmHg at 25°C
• Boiling Point: 318.7 °C at 760 mmHg
• Flash Point: 146.6 °C
• PSA: 38.05000
• LogP: 2.58400
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Isoindolin-5-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoindolin-5-amine hydrochloride

There total 2 articles about Isoindolin-5-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

isoindoline (496-12-8) → 5-aminoisoindoline hydrochloride (503614-81-1)

Guidance literature:

With hydrogenchloride; Pd(OH)2/C; In ethanol;

Reference yield: 36.0%

2,3-Dihydro-5-nitro-2-(phenylmethyl)-1H-isoindole (127168-68-7) → 5-aminoisoindoline hydrochloride (503614-81-1)

Guidance literature:

2,3-Dihydro-5-nitro-2-(phenylmethyl)-1H-isoindole; With 20% palladium hydroxide-activated charcoal; hydrogen; In ethanol; under 2327.23 Torr;

With hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen; In ethanol; water; under 2585.81 Torr;

Reference yield: 86.0%

3-hydroxy-1-(4-iodophenyl)-4-(2,2,2-trifluoroacetyl)-5,6-dihydropyridin-2(1H)-one (503615-04-1) + 5-aminoisoindoline hydrochloride (503614-81-1) + acetic acid (64-19-7,77671-22-8) → C21H16F3IN4O*C2H4O2

Guidance literature:

5-aminoisoindoline hydrochloride; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 0.666667h;

acetic acid; With hydrogenchloride; tin(ll) chloride; In water; at 0 - 10 ℃; for 2h;

3-hydroxy-1-(4-iodophenyl)-4-(2,2,2-trifluoroacetyl)-5,6-dihydropyridin-2(1H)-one; In methanol; water; at 50 ℃; for 16h;

upstream raw materials:

isoindoline

2,3-Dihydro-5-nitro-2-(phenylmethyl)-1H-isoindole