3-(4-Chlorphenyl)-4,5,6,7-tetrahydroisoxazolo<4,5-b>pyrazin

Base Information

Chemical Name:3-(4-Chlorphenyl)-4,5,6,7-tetrahydroisoxazolo<4,5-b>pyrazin
CAS No.:134140-92-4
Molecular Formula:C₁₁H₁₀ClN₃O
Molecular Weight:235.673
Hs Code.:

Synonyms:

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Chemical Property of 3-(4-Chlorphenyl)-4,5,6,7-tetrahydroisoxazolo<4,5-b>pyrazin

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Technology Process of 3-(4-Chlorphenyl)-4,5,6,7-tetrahydroisoxazolo<4,5-b>pyrazin

There total 3 articles about 3-(4-Chlorphenyl)-4,5,6,7-tetrahydroisoxazolo<4,5-b>pyrazin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.8%

: 6315-52-2
1,2-bis-tosyloxyethane

: 134140-90-2
4,5-Diamino-3-(4-chlorphenyl)isoxazol

: 134140-92-4
3-(4-Chlorphenyl)-4,5,6,7-tetrahydroisoxazolo<4,5-b>pyrazin

Guidance literature:: With sodium hydrogencarbonate; In diethylene glycol dimethyl ether; for 3h; Heating;
DOI:10.1002/ardp.19913240303

Reference yield:

: 134140-88-8
5-Amino-4-carboxyethyl-3-(4-chlorphenyl)isoxazol

: 134140-92-4
3-(4-Chlorphenyl)-4,5,6,7-tetrahydroisoxazolo<4,5-b>pyrazin

Guidance literature:: Multi-step reaction with 5 steps

1: 21 percent / 2N KOH / 2 h / Heating

2: 2) 96percent HNO₃ / 1) 80-100 deg C, 1.5 h, 2a) -10 deg C, b) 0 deg C, 1 h, c) r.t., overnight

3: 20percent H₂SO₄ / ethanol / 3 h / Heating

4: 1.08 g / NaBH₄, H₂O / 10percent Pd/C / dioxane / Ambient temperature; 6-10 h

5: 2.8 percent / NaHCO₃ / bis-(2-methoxy-ethyl) ether / 3 h / Heating

With potassium hydroxide; sodium tetrahydroborate; sulfuric acid; water; nitric acid; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; diethylene glycol dimethyl ether;
DOI:10.1002/ardp.19913240303

Reference yield:

: N-[3-(4-Chloro-phenyl)-4-nitro-isoxazol-5-yl]-acetamide

: 134140-92-4
3-(4-Chlorphenyl)-4,5,6,7-tetrahydroisoxazolo<4,5-b>pyrazin

Guidance literature:: Multi-step reaction with 3 steps

1: 20percent H₂SO₄ / ethanol / 3 h / Heating

2: 1.08 g / NaBH₄, H₂O / 10percent Pd/C / dioxane / Ambient temperature; 6-10 h

3: 2.8 percent / NaHCO₃ / bis-(2-methoxy-ethyl) ether / 3 h / Heating

With sodium tetrahydroborate; sulfuric acid; water; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; diethylene glycol dimethyl ether;
DOI:10.1002/ardp.19913240303