2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-quinolin-3-ylmethyl-1H-pyrimidin-4-one; hydrochloride

Base Information

• Chemical Name: 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-quinolin-3-ylmethyl-1H-pyrimidin-4-one; hydrochloride
• CAS No.: 71351-28-5
• Molecular Formula: 5C₂₁H₂₂N₆OS*14ClH
• Molecular Weight: 2543.01
• Mol file: 71351-28-5.mol

Synonyms:

Chemical Property of 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-quinolin-3-ylmethyl-1H-pyrimidin-4-one; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-quinolin-3-ylmethyl-1H-pyrimidin-4-one; hydrochloride

There total 7 articles about 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-quinolin-3-ylmethyl-1H-pyrimidin-4-one; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(Methylthio)-5-[(3-quinolinyl)-methyl]-4(3H) pyrimidinone (71351-32-1) + 4-{[(2-aminoethyl)thio]methyl}-5-methylimidazole (38585-67-0) → 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-quinolin-3-ylmethyl-1H-pyrimidin-4-one; hydrochloride (71351-28-5,122945-88-4)

Guidance literature:

With hydrogenchloride; at 145 - 150 ℃; for 5h;

DOI:10.1016/0223-5234(89)90166-9

Reference yield:

3-quinolylcarboxaldehyde (13669-42-6) → 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-quinolin-3-ylmethyl-1H-pyrimidin-4-one; hydrochloride (71351-28-5,122945-88-4)

Guidance literature:

Multi-step reaction with 7 steps

1: pyridine, piperidine

2: conc. H₂SO₄

3: H₂ / 5percent Pd/C / ethanol / 45 °C

4: sodium wire / diethyl ether / 18 h / Ambient temperature

5: ethanol / 7 h / Heating

6: 75 percent / NaOH / H₂O; ethanol / 60 °C

7: 68 percent / 2.) ethanolic hydrogen chloride / 5 h / 145 - 150 °C

With piperidine; pyridine; hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol; water;

DOI:10.1016/0223-5234(89)90166-9

Reference yield:

(E)-3-Quinolin-3-yl-acrylic acid ethyl ester (71351-29-6) → 2-[2-(5-Methyl-1H-imidazol-4-ylmethylsulfanyl)-ethylamino]-5-quinolin-3-ylmethyl-1H-pyrimidin-4-one; hydrochloride (71351-28-5,122945-88-4)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / 5percent Pd/C / ethanol / 45 °C

2: sodium wire / diethyl ether / 18 h / Ambient temperature

3: ethanol / 7 h / Heating

4: 75 percent / NaOH / H₂O; ethanol / 60 °C

5: 68 percent / 2.) ethanolic hydrogen chloride / 5 h / 145 - 150 °C

With hydrogenchloride; sodium hydroxide; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol; water;

DOI:10.1016/0223-5234(89)90166-9

upstream raw materials:

2-(Methylthio)-5-[(3-quinolinyl)-methyl]-4(3H) pyrimidinone

4-{[(2-aminoethyl)thio]methyl}-5-methylimidazole

3-quinolylcarboxaldehyde

(E)-3-Quinolin-3-yl-acrylic acid ethyl ester