(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-acetylamino}-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid

Base Information

• Chemical Name: (S)-2-[(S)-2-{2-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-acetylamino}-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid
• CAS No.: 127292-66-4
• Molecular Formula: C₃₀H₄₃N₇O₈
• Molecular Weight: 629.714
• Mol file: 127292-66-4.mol

Synonyms:

Chemical Property of (S)-2-[(S)-2-{2-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-acetylamino}-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-2-{2-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-acetylamino}-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid

There total 5 articles about (S)-2-[(S)-2-{2-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-acetylamino}-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Benzyloxycarbonylamino-3-methyl-butyric acid 4-nitro-phenyl ester (3411-74-3,4108-18-3,10512-93-3,10512-94-4) → (S)-2-[(S)-2-{2-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-acetylamino}-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid (127292-66-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / aq. NaOH

2: 1.) hydrogen / 1.) Pd/C / 1.) methanol, 2.) 1 N NaOH, dioxane

With hydrogen; palladium on activated charcoal; In sodium hydroxide;

DOI:10.1007/BF00597661

Reference yield:

N-(N-benzyloxycarbonyl-L-valyl)-glycine (22221-75-6,74088-26-9,2790-84-3) → (S)-2-[(S)-2-{2-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-acetylamino}-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid (127292-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) hydrogen / 1.) Pd/C / 1.) methanol, 2.) 1 N NaOH, dioxane

With hydrogen; palladium on activated charcoal;

DOI:10.1007/BF00597661

Reference yield:

2-Benzyloxycarbonylamino-propionic acid 4-nitro-phenyl ester (1168-87-2,4108-17-2,30960-00-0) → (S)-2-[(S)-2-{2-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-acetylamino}-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoic acid (127292-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) hydrogen / 1.) Pd/C / 1.) methanol, 2.) 1 N NaOH, dioxane

With hydrogen; palladium on activated charcoal;

DOI:10.1007/BF00597661

upstream raw materials:

N-(N-benzyloxycarbonyl-L-valyl)-glycine

2-Benzyloxycarbonylamino-propionic acid 4-nitro-phenyl ester

4-[2-tert-Butoxycarbonylamino-2-(4-nitro-phenoxycarbonyl)-ethyl]-imidazole-1-carboxylic acid tert-butyl ester

L-leucine