Adenosine-13C5

Base Information

• Chemical Name: Adenosine-13C5
• CAS No.: 159496-13-6
• Molecular Formula: C513C5H13N5O4
• Molecular Weight: 272
• Mol file: 159496-13-6.mol

Synonyms:Adenosine-13C5;1-(6-AMino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranose-13C5;9-β-D-Ribofuranosyl-9H-purin-6-aMine-13C5;9-β-D-Ribofuranosyladenine-13C5;Adenine Riboside-13C5;Adenocard-13C5;Adenocor-13C5;Adenogesic-13C5

Chemical Property of Adenosine-13C5

Chemical Property:

• Melting Point: 233-235°C (dec.)
• PSA: 139.54000
• LogP: -1.39880
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

Adenosine-13C5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Labelled nucleotide.

Technology Process of Adenosine-13C5

There total 9 articles about Adenosine-13C5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)adenine (503173-77-1) → [1′,2′,3′,4′,5′-13C5] adenosine (159496-13-6,201996-55-6)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 48h;

DOI:10.1016/S0040-4020(02)01246-2

Reference yield:

<1,2,3,4,5-13C5>-1,2-O-isopropylidene-α-D-ribofuranose (238096-51-0) → [1′,2′,3′,4′,5′-13C5] adenosine (159496-13-6,201996-55-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 95 percent / pyridine / 3 h / 20 °C

2.1: 87 percent / H₂SO₄; AcOH / 20 °C

3.1: HMDS; (NH₄)2SO₄ / Heating

3.2: 68 percent / TMSOTf / CH₂Cl₂ / 3.5 h / Heating

4.1: 98 percent / NH₃ / methanol / 48 h / 20 °C

With pyridine; ammonium sulfate; sulfuric acid; ammonia; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol;

DOI:10.1016/S0040-4020(02)01246-2

Reference yield:

[ribose-13C5]-3,5-di-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranose (503173-74-8) → [1′,2′,3′,4′,5′-13C5] adenosine (159496-13-6,201996-55-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 87 percent / H₂SO₄; AcOH / 20 °C

2.1: HMDS; (NH₄)2SO₄ / Heating

2.2: 68 percent / TMSOTf / CH₂Cl₂ / 3.5 h / Heating

3.1: 98 percent / NH₃ / methanol / 48 h / 20 °C

With ammonium sulfate; sulfuric acid; ammonia; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol;

DOI:10.1016/S0040-4020(02)01246-2

upstream raw materials:

adenine

[13C5]-1,2-di-O-acetyl-3,5-di-O-benzoyl-α,β-D-ribofuranose

[ribose-13C5]-1-(2-O-acetyl-3,5-di-O-benzoyl-β-D-ribofuranosyl)adenine

<1,2,3,4,5-13C5>-1,2-O-isopropylidene-α-D-ribofuranose