(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester
CAS No.:123130-00-7
Molecular Formula:C₂₈H₅₁NO₇SSi₂
Molecular Weight:601.952
Hs Code.:

(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester

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Chemical Property of (3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester

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Technology Process of (3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester

There total 6 articles about (3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 123129-99-7
(3R,4S)-3-Hydroxy-4-((S)-1-hydroxy-2-methanesulfonyloxy-ethyl)-piperidine-1-carboxylic acid benzyl ester

: 123130-00-7
(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: With 2,6-dimethylpyridine;
DOI:10.1039/P19890001067

Reference yield:

: (3aR,5S,6R,6aR)-6-(2-Azido-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole-5-carbaldehyde

: 123130-00-7
(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium borohydride / ethanol

2: 50percent aq. CF₃COOH

3: 1.) H₂ / 1.) 10percent Pd on carbon / 1.) aq. MeOH, 50 deg C, 250 p.s.i.

4: 61 percent / pyridine / -30 °C

5: 86 percent / 2,6-lutidine

With pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1039/P19890001067

Reference yield:

: (R)-1-[(3aR,5S,6R,6aR)-6-(2-Azido-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol

: 123130-00-7
(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-2-methanesulfonyloxy-ethyl]-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium periodate

2: sodium borohydride / ethanol

3: 50percent aq. CF₃COOH

4: 1.) H₂ / 1.) 10percent Pd on carbon / 1.) aq. MeOH, 50 deg C, 250 p.s.i.

5: 61 percent / pyridine / -30 °C

6: 86 percent / 2,6-lutidine

With pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1039/P19890001067