Technology Process of (S)-1-Benzoyl-5-benzyl-3-[(8E,10E,12E)-(4S,6S)-4,6,12-trimethyl-4-(2-trimethylsilanyl-ethoxymethoxy)-tetradeca-8,10,12-trienoyl]-1,5-dihydro-pyrrol-2-one
There total 20 articles about (S)-1-Benzoyl-5-benzyl-3-[(8E,10E,12E)-(4S,6S)-4,6,12-trimethyl-4-(2-trimethylsilanyl-ethoxymethoxy)-tetradeca-8,10,12-trienoyl]-1,5-dihydro-pyrrol-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 15 steps
1: 95 percent / N-chlorosuccinimide, Me2S, Et3N / CH2Cl2 / -20 °C
2: 70 percent
3: 85 percent / Et2N-i-Pr
4: 70 percent / Dowex 50W-X8
5: 95 percent / H2 / Pd/C / methanol
6: 90 percent / DMSO, oxalyl chloride
7: 70 percent
8: 1.) 9-BBN, 2.) H2O2, base
9: 90 percent / DMSO, oxalyl chloride
11: 90 percent / NaOH / methanol; H2O
12: 90 percent
13: LiN(SiMe3)2
14: 95 percent / LiN(SiMe3)2
15: MCPBA, H2O2 / 1.) -40 deg C, 15 min, 2.) 0 deg C
With
sodium hydroxide; N-chloro-succinimide; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; dimethylsulfide; N,N-diethyl-N-isopropylamine; Dowex 50W-X8; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
DOI:10.1039/c39860000724
- Guidance literature:
-
Multi-step reaction with 13 steps
1: 85 percent / Et2N-i-Pr
2: 70 percent / Dowex 50W-X8
3: 95 percent / H2 / Pd/C / methanol
4: 90 percent / DMSO, oxalyl chloride
5: 70 percent
6: 1.) 9-BBN, 2.) H2O2, base
7: 90 percent / DMSO, oxalyl chloride
9: 90 percent / NaOH / methanol; H2O
10: 90 percent
11: LiN(SiMe3)2
12: 95 percent / LiN(SiMe3)2
13: MCPBA, H2O2 / 1.) -40 deg C, 15 min, 2.) 0 deg C
With
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; N,N-diethyl-N-isopropylamine; Dowex 50W-X8; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
methanol; water;
DOI:10.1039/c39860000724
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 70 percent / Dowex 50W-X8
2: 95 percent / H2 / Pd/C / methanol
3: 90 percent / DMSO, oxalyl chloride
4: 70 percent
5: 1.) 9-BBN, 2.) H2O2, base
6: 90 percent / DMSO, oxalyl chloride
8: 90 percent / NaOH / methanol; H2O
9: 90 percent
10: LiN(SiMe3)2
11: 95 percent / LiN(SiMe3)2
12: MCPBA, H2O2 / 1.) -40 deg C, 15 min, 2.) 0 deg C
With
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; Dowex 50W-X8; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
methanol; water;
DOI:10.1039/c39860000724
