Technology Process of 1-{4-[2-(2,5-dimethylpyrrol-1-yl)-pyrimidin-5-yl]phenyl}cyclobutanecarboxylic acid
There total 3 articles about 1-{4-[2-(2,5-dimethylpyrrol-1-yl)-pyrimidin-5-yl]phenyl}cyclobutanecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene / 5 h / 140 °C
2: water; lithium hydroxide / tetrahydrofuran / 24 h / 60 °C
With
water; toluene-4-sulfonic acid; lithium hydroxide;
In
tetrahydrofuran; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C
1.2: 0 - 20 °C
2.1: potassium hydroxide / ethanol / 48 h / 110 °C
3.1: thionyl chloride / 0 - 60 °C
4.1: sodium carbonate / tetrahydrofuran / 0.5 h / 120 °C / Microwave irradiation
5.1: toluene-4-sulfonic acid / toluene / 5 h / 140 °C
6.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 60 °C
With
thionyl chloride; water; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; lithium hydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium hydroxide / ethanol / 48 h / 110 °C
2: thionyl chloride / 0 - 60 °C
3: sodium carbonate / tetrahydrofuran / 0.5 h / 120 °C / Microwave irradiation
4: toluene-4-sulfonic acid / toluene / 5 h / 140 °C
5: water; lithium hydroxide / tetrahydrofuran / 24 h / 60 °C
With
thionyl chloride; water; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; lithium hydroxide;
In
tetrahydrofuran; ethanol; toluene;
