(E)-N-(2-fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:(E)-N-(2-fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
CAS No.:319460-94-1
Molecular Formula:C26H22FN7O
Molecular Weight:467.5
Hs Code.:
UNII:BK72RP7F7D
Nikkaji Number:J2.393.064A
Pharos Ligand ID:84SY6JQS94LK
ChEMBL ID:CHEMBL3545335
Mol file:319460-94-1.mol

Synonyms:319460-94-1;AG-13958;AG13958;AG 13958;(E)-N-(2-fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide;BK72RP7F7D;AG-013958;1H-Pyrazole-5-carboxamide, N-(2-fluoro-5-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-;UNII-BK72RP7F7D;SCHEMBL5247290;SCHEMBL6491425;CHEMBL3545335;JXSVVZKPEDIRTN-DHZHZOJOSA-N;BCPP000423;BCP01979;N-[2-Fluoro-5-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]amino]phenyl]-2,5-dimethylpyrazole-3-carboxamide;s2211;AKOS015904194;BCP9000248;NCGC00387023-01;(E)-N-(2-fluoro-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylamino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide;AG013958;HY-15492;CS-0006794;A875759;J-502056

Suppliers and Price of (E)-N-(2-fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide 97%
5g
$ 10800.00

Matrix Scientific
(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide 97%
500mg
$ 4250.00

DC Chemicals
AG13958 >98%
250 mg
$ 1200.00

DC Chemicals
AG13958 >98%
100 mg
$ 750.00

DC Chemicals
AG13958 >98%
1 g
$ 2600.00

ChemScene
AG-13958 99.64%
100mg
$ 3700.00

ChemScene
AG-13958 99.64%
50mg
$ 2200.00

ChemScene
AG-13958 99.64%
10mg
$ 720.00

ChemScene
AG-13958 99.64%
5mg
$ 425.00

Biosynth Carbosynth
AG 13958
5 mg
$ 480.00

Total 11 raw suppliers

Chemical Property of (E)-N-(2-fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

Chemical Property:

Boiling Point:647.8±55.0 °C(Predicted)
PKA:12.13±0.70(Predicted)
PSA：100.52000
Density:1.35±0.1 g/cm3(Predicted)
LogP:5.45120
XLogP3:4.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:467.18698651
Heavy Atom Count:35
Complexity:753

Purity/Quality:

97% ^*data from raw suppliers

(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NN(C(=C1)C(=O)NC2=C(C=CC(=C2)NC3=CC4=C(C=C3)C(=NN4)C=CC5=CC=CC=N5)F)C
Isomeric SMILES:CC1=NN(C(=C1)C(=O)NC2=C(C=CC(=C2)NC3=CC4=C(C=C3)C(=NN4)/C=C/C5=CC=CC=N5)F)C
Recent EU Clinical Trials:A Phase 1/2, Randomized, Masked, Single and Multiple-Dose, Sequential Dose-Escalation Study of the Safety and Efficacy of AG-013958 in Subjects with Subfoveal Choroidal Neovascularization Associated with Age-related Macular Degeneration

Technology Process of (E)-N-(2-fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

There total 4 articles about (E)-N-(2-fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

: C₃₁H₃₀FN₇O₂

: 319460-94-1
AG-013958

Guidance literature:: C₃₁H₃₀FN₇O₂; With methanol; toluene-4-sulfonic acid; at 68 ℃; for 18h;

With potassium carbonate; In water; isopropyl alcohol; at 20 ℃; for 3h; Product distribution / selectivity;