3-amino-N-(2,3-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide

Base Information

Chemical Name:3-amino-N-(2,3-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide
CAS No.:354119-24-7
Molecular Formula:C₂₁H₂₃N₃OS
Molecular Weight:365.499
Hs Code.:
European Community (EC) Number:648-681-9
ChEMBL ID:CHEMBL3759209
Mol file:354119-24-7.mol

Synonyms:3-amino-N-(2,3-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide;Oprea1_527102;Oprea1_867750;CHEMBL3759209;AKOS001644423;AN-919/37393008;SR-01000467391;SR-01000467391-1;6-amino-N-(2,3-dimethylphenyl)-4-thia-2-azatricyclo[7.5.0.03,7]tetradeca-1,3(7),5,8-tetraene-5-carboxamide

Suppliers and Price of 3-amino-N-(2,3-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-AMINO-N-(2,3-DIMETHYLPHENYL)-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[B]THIENO[3,2-E]PYRIDINE-2-CARBOXAMIDE 95.00%
5MG
$ 505.43

Total 0 raw suppliers

Chemical Property of 3-amino-N-(2,3-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:365.15618354
Heavy Atom Count:26
Complexity:516

Purity/Quality:: 3-AMINO-N-(2,3-DIMETHYLPHENYL)-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA[B]THIENO[3,2-E]PYRIDINE-2-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)NC(=O)C2=C(C3=C(S2)N=C4CCCCCC4=C3)N)C

Technology Process of 3-amino-N-(2,3-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide

There total 4 articles about 3-amino-N-(2,3-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2-thioxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[b]pyridinecarbonitrile

: 349120-89-4
2-bromo-N-(2',3'-dimethylphenyl)acetamide

: 354119-24-7
3-amino-N-(2',3'-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide

Guidance literature:: With sodium carbonate; In ethanol; at 100 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.01.047

Reference yield:

: 154383-98-9
sodium (2-oxocycloheptylidene)methanolate

: 354119-24-7
3-amino-N-(2',3'-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; piperidine / water / 4 h / Inert atmosphere; Reflux

2: sodium carbonate / ethanol / 18 h / 100 °C / Inert atmosphere

With piperidine; sodium carbonate; acetic acid; In ethanol; water;
DOI:10.1016/j.bmc.2016.01.047

Reference yield:

: 87-59-2
2,3-Dimethylaniline

: 354119-24-7
3-amino-N-(2',3'-dimethylphenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1 h / 0 °C / Inert atmosphere

2: sodium carbonate / ethanol / 18 h / 100 °C / Inert atmosphere

With sodium carbonate; triethylamine; In ethanol;
DOI:10.1016/j.bmc.2016.01.047