(8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione

Base Information

Chemical Name:(8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione
CAS No.:1334484-44-4
Molecular Formula:C₃₃H₄₀O₆S
Molecular Weight:564.743
Hs Code.:

(8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione

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Chemical Property of (8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione

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Technology Process of (8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione

There total 4 articles about (8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1334484-25-1
2-fluoro-6-(1-cyclopropyl-2-(phenylsulfonyl)allyloxy)pyridine

: 1334484-32-0
O-ethyl S-(2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl) carbonodithioate

: 1334484-44-4
(8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione

Guidance literature:: With dilauryl peroxide; In ethyl acetate; Inert atmosphere; Reflux;
DOI:10.1021/ja207944c

Reference yield:

: 1334484-52-4
2-(1-cyclopropyl-2-(phenylthio)allyloxy)-6-fluoropyridine

: 1334484-44-4
(8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

With dilauryl peroxide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; ethyl acetate;
DOI:10.1021/ja207944c

Reference yield:

: 1334484-51-3
C₁₂H₁₄OS

: 1334484-44-4
(8S,9S,10R,13S,14S,17R)-17-((E)-5-cyclopropyl-4-(phenylsulfonyl)pent-4-enoyl)-17-hydroxy-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.33 h / Inert atmosphere

1.2: Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

With dilauryl peroxide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide; ethyl acetate; mineral oil;
DOI:10.1021/ja207944c