(4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

Base Information

Chemical Name:(4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one
CAS No.:937816-17-6
Molecular Formula:C14H14F3NO2
Molecular Weight:285.266
Hs Code.:
Mol file:937816-17-6.mol

Synonyms:(4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

Suppliers and Price of (4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one 95+%
1g
$ 772.00

American Custom Chemicals Corporation
(4R,9AS)-4-(3,4,5-TRIFLUOROPHENYL)HEXAHYDROPYRIDO[2,1-C][1,4]OXAZIN-6(1H)-ONE 95.00%
1G
$ 1204.35

American Custom Chemicals Corporation
(4R,9AS)-4-(3,4,5-TRIFLUOROPHENYL)HEXAHYDROPYRIDO[2,1-C][1,4]OXAZIN-6(1H)-ONE 95.00%
5MG
$ 503.65

Alichem
(4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one
1g
$ 665.68

Total 5 raw suppliers

Chemical Property of (4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

Chemical Property:

PSA：29.54000
LogP:2.49420
Storage Temp.:2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

(4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

There total 2 articles about (4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

: 1166395-02-3
4-[(3S,5R)-5-(3,4,5-trifluorophenyl)morpholin-3-yl]butanoic acid monohydrochloride

: 543-27-1
isobutyl chloroformate

: 937816-17-6
(4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

Guidance literature:: 4-[(3S,5R)-5-(3,4,5-trifluorophenyl)morpholin-3-yl]butanoic acid monohydrochloride; With triethylamine; In Isopropyl acetate; acetonitrile; at 16 ℃; Inert atmosphere;

isobutyl chloroformate; In Isopropyl acetate; acetonitrile; at 174 ℃; Inert atmosphere;

Reference yield:

: 937816-16-5
(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one

: 937816-17-6
(4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; at 20 ℃; for 2h;

Reference yield:

: 937816-17-6
(4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

: C₁₄H₁₃F₃INO₂

Guidance literature:: (4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one; With trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; In dichloromethane; at 0 ℃; for 0.5h;

With iodine; In dichloromethane; at 0 ℃; for 1h;