(R)-2-(1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid

Base Information

Chemical Name:(R)-2-(1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid
CAS No.:1173900-36-1
Molecular Formula:C23H26N4O4
Molecular Weight:422.484
Hs Code.:
Mol file:1173900-36-1.mol

Synonyms:(R)-Methyl 2-(1-(2-(2-ethoxyethylaMino)-7-Methyl-4-oxo-4H-pyrido[1,2-a]pyriMidin-9-yl)ethylaMino)benzoate;Benzoic acid, 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-, methyl ester

Suppliers and Price of (R)-2-(1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

ChemScene
(R)-methyl2-(1-(2-(2-ethoxyethylamino)-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoate
25mg
$ 418.00

ChemScene
(R)-methyl2-(1-(2-(2-ethoxyethylamino)-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoate
1g
$ 3630.00

Chemenu
(R)-methyl2-(1-(2-(2-ethoxyethylamino)-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoate 95%+
100mg
$ 1840.00

Total 7 raw suppliers

Chemical Property of (R)-2-(1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

(R)-methyl2-(1-(2-(2-ethoxyethylamino)-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
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Technology Process of (R)-2-(1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid

There total 5 articles about (R)-2-(1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.9%

: 610-96-8
methyl chlorobenzoate

: 9-(1R-aminoethyl)-7-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

: 1173900-36-1,1173900-38-3
2-[[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid methyl ester

Guidance literature:: With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 90 ℃; for 12h; Inert atmosphere;

Reference yield:

: 3-acetyl-5-methyl-2-pyridone

: 1173900-36-1,1173900-38-3
2-[[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / dichloromethane / 2 h / 0 - 20 °C

2.1: bis[di(trimethylsilyl)amine] zinc; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 2 h / 50 - 60 °C

3.1: toluene-4-sulfonic acid / toluene / 48 h / Reflux

4.1: titanium(IV) tetraethanolate; (S)-2-methylpropane-2-sulfinamide / tetrahydrofuran / 24 h / Inert atmosphere; Reflux

4.2: 4 h / -50 - 20 °C / Inert atmosphere

5.1: copper(l) iodide; L-proline; potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C / Inert atmosphere

With titanium(IV) tetraethanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tri-tert-butyl phosphine; bis[di(trimethylsilyl)amine] zinc; potassium carbonate; toluene-4-sulfonic acid; L-proline; (S)-2-methylpropane-2-sulfinamide; trichlorophosphate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 885223-64-3
2-chloro-3-acetyl-5-methylpyridine

: 1173900-36-1,1173900-38-3
2-[[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis[di(trimethylsilyl)amine] zinc; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 2 h / 50 - 60 °C

2.1: toluene-4-sulfonic acid / toluene / 48 h / Reflux

3.1: titanium(IV) tetraethanolate; (S)-2-methylpropane-2-sulfinamide / tetrahydrofuran / 24 h / Inert atmosphere; Reflux

3.2: 4 h / -50 - 20 °C / Inert atmosphere

4.1: copper(l) iodide; L-proline; potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C / Inert atmosphere

With titanium(IV) tetraethanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tri-tert-butyl phosphine; bis[di(trimethylsilyl)amine] zinc; potassium carbonate; toluene-4-sulfonic acid; L-proline; (S)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; dimethyl sulfoxide; toluene;