4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)-alpha,alpha-dimethylbenzeneacetonitrile

Base Information

Chemical Name:4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)-alpha,alpha-dimethylbenzeneacetonitrile
CAS No.:1201643-72-2
Molecular Formula:C22H17BrN4O
Molecular Weight:433.307
Hs Code.:
Mol file:1201643-72-2.mol

Synonyms:4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)-alpha,alpha-dimethylbenzeneacetonitrile;

Suppliers and Price of 4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)-alpha,alpha-dimethylbenzeneacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
2-(4-(3-acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
500mg
$ 1430.00

Chemenu
2-(4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 95%+
250mg
$ 1859.00

Chemenu
2-(4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 95%+
100mg
$ 1201.00

Total 10 raw suppliers

Chemical Property of 4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)-alpha,alpha-dimethylbenzeneacetonitrile

Chemical Property:

PSA：71.57000
Density:1.43
LogP:5.47528

Purity/Quality:

99% ^*data from raw suppliers

2-(4-(3-acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)-alpha,alpha-dimethylbenzeneacetonitrile

There total 21 articles about 4-(3-Acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)-alpha,alpha-dimethylbenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1201643-77-7
2-(4-((3-amino-6-bromoquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

: 108-24-7
acetic anhydride

: 1201643-72-2
2-(4-(3-acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With potassium acetate; In toluene;

Reference yield:

: 40119-34-4
2-methyl-2-(4-methylphenyl)propionitrile

: 1201643-72-2
2-(4-(3-acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: pyridine; potassium permanganate / water / 1 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

3.2: 25 °C

4.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

5.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

6.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

7.1: hydrogenchloride / acetone / 24 h

8.1: hydrogenchloride / water / 24 h

9.1: potassium acetate / ethanol / 5 h / Reflux

10.1: hydrogenchloride; titanium(III) chloride

11.1: potassium acetate / toluene

With pyridine; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium permanganate; titanium(III) chloride; oxalyl dichloride; potassium acetate; caesium carbonate; ozone; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1201643-75-5
(E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid

: 1201643-72-2
2-(4-(3-acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / acetic anhydride / 1.5 h / 120 °C

2.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 2 h / 0 - 100 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 - 20 °C

4.1: hydrogen / Reney-Ni / tetrahydrofuran

5.1: potassium acetate / toluene

With hydrogen; potassium acetate; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; trichlorophosphate; Reney-Ni; In tetrahydrofuran; acetic anhydride; toluene; acetonitrile;