(S)-tert-butyl 3-hydroxypent-4-enoate

Base Information

• Chemical Name: (S)-tert-butyl 3-hydroxypent-4-enoate
• CAS No.: 1040390-31-5
• Molecular Formula: C₉H₁₆O₃
• Molecular Weight: 172.224
• Mol file: 1040390-31-5.mol

Synonyms:(S)-2-t-butoxycarbonylamino-3,3-diphenylpropan-1-ol;3-Phenyl-L-phenylalaninol,N-BOC protected;(S)-2-Amino-3,3-diphenylpropan-1-ol,N-BOC protected;N-(TERT-BUTOZYCARBONYL)-3-PHENYL-L-PHENYLALANINOL;(3S)-3-hydroxy-4-pentenoic acid tert-butyl ester;(S)-tert-butyl 3-hydroxypent-4-enoate;t-butyl (S)-N-(2-hydroxy-1-(diphenylmethyl)ethyl)carbamate;tert-butyl (S)-3-hydroxypent-4-enoate;(S)-tert-butyl 3-hydroxy-1,1-diphenylpropan-2-ylcarbamate;N-Boc-p-Phenyl-L-Phenylalaninol;N-(TERT-BUTOXYCARBONYL)-3-PHENYL-L-PHENYLALANINOL;tert-butyl (S)-3-hydroxy-4-pentenoate;

Chemical Property of (S)-tert-butyl 3-hydroxypent-4-enoate

Chemical Property:

• Boiling Point: 238℃
• Flash Point: 91℃
• PSA: 46.53000
• Density: 0.992
• LogP: 1.26510

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-tert-butyl 3-hydroxypent-4-enoate

There total 8 articles about (S)-tert-butyl 3-hydroxypent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3S)-3-acetoxy-4-pentenoic acid tert-butyl ester (172516-15-3) → (3S)-3-hydroxy-4-pentenoic acid tert-butyl ester (1040390-31-5)

Guidance literature:

With methanol; potassium carbonate; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jm100244y

Reference yield: 48.0%

tert-butyl 3-hydroxypent-4-enoate (122763-67-1) → (3S)-3-hydroxy-4-pentenoic acid tert-butyl ester (1040390-31-5)

Guidance literature:

With vinyl acetate; Amano Lipase PS; In pentane; at 30 ℃; for 3h; stereoselective reaction; Molecular sieve; Enzymatic reaction;

DOI:10.1002/ejoc.201501325

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + tert-butyl 3-hydroxypent-4-enoate (122763-67-1) → C11H18O4 + (3S)-3-acetoxy-4-pentenoic acid tert-butyl ester (172516-15-3) + (3S)-3-hydroxy-4-pentenoic acid tert-butyl ester (1040390-31-5) + (R)-tert-butyl 3-hydroxypent-4-enoate (220861-37-0)

Guidance literature:

With Amano PS-D lipase; In pentane; at 35 ℃; for 3h;

DOI:10.1021/ol071266e

upstream raw materials:

(3S)-3-acetoxy-4-pentenoic acid tert-butyl ester

vinyl acetate

tert-butyl 3-hydroxypent-4-enoate

lithium tert-butyl acetate