2-Piperidinecarboxylicacid,2-methyl-,(R)-(9CI)

Base Information

• Chemical Name: 2-Piperidinecarboxylicacid,2-methyl-,(R)-(9CI)
• CAS No.: 105141-61-5
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Hs Code.: 2933399090
• Mol file: 105141-61-5.mol

Synonyms:2-Piperidinecarboxylicacid,2-methyl-,(R)-(9CI);(R)-2-Methylpiperidine-2-carboxylic acid;2-Piperidinecarboxylicacid,2-Methyl-,(2R);2-Methyl-2-(2R)-piperidinecarboxylic acid

Chemical Property of 2-Piperidinecarboxylicacid,2-methyl-,(R)-(9CI)

Chemical Property:

• Melting Point: 345-350℃ (dec.)
• PSA: 49.33000
• LogP: 0.93200

Purity/Quality:

99%, ^*data from raw suppliers

(R)-2-Methylpiperidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Piperidinecarboxylicacid,2-methyl-,(R)-(9CI)

There total 7 articles about 2-Piperidinecarboxylicacid,2-methyl-,(R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(2R)-2-methyl-2-piperidinecarboxamide (132259-55-3) → (R)-2-methyl-2-piperidinecarboxylic acid (105141-61-5)

Guidance literature:

With hydrogenchloride; for 18h; Heating;

Reference yield:

(S)-3-Isopropyl-1-methoxy-9a-methyl-3,6,7,8,9,9a-hexahydro-pyrido[1,2-a]pyrazin-4-one (105141-59-1) → L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + (R)-2-methyl-2-piperidinecarboxylic acid (105141-61-5)

Guidance literature:

With hydrogen bromide; methyloxirane; Yield given. Multistep reaction. Yields of byproduct given; 1.) 18 h, reflux, 2.) reflux, ethanol;

Reference yield:

(4R,9aR)-9a-Methyl-4-phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one (874368-20-4) → (R)-2-methyl-2-piperidinecarboxylic acid (105141-61-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; water; at 20 ℃; for 24h; under 3750.3 Torr;

DOI:10.1016/j.tetasy.2005.10.025

upstream raw materials:

(2R)-2-methyl-2-piperidinecarboxamide

(S)-3-Isopropyl-1-methoxy-9a-methyl-3,6,7,8,9,9a-hexahydro-pyrido[1,2-a]pyrazin-4-one

(4R,9aR)-9a-Methyl-4-phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one

2-methyl-3,4,5,6-tetrahydropyridine-1-oxide

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