(R)-2-(methoxycarbonylamino)-3-phenylpropanoic acid

Base Information

• Chemical Name: (R)-2-(methoxycarbonylamino)-3-phenylpropanoic acid
• CAS No.: 67401-65-4
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Mol file: 67401-65-4.mol

Synonyms:Fmoc-D-serine;(R)-N-(methoxycarbonyl)phenylalanine;N-methoxycarbonyl-D-phenylalanine;N-Fmoc-D-serine;(R)-N-(fluoren-9-ylmethoxycarbonyl)serine;(R)-2-(methoxycarbonylamino)-3-phenylpropanoic acid;N-(9-fluorenylmethyloxycarbonyl)-D-serine;fmoc-Ser-OH;Fmoc-D-Ser-OH;(R)-N-carbomethoxy phenylalanine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-serine;(R)-2-(Methoxycarbonylamino)-3-phenylpropanic acid;

Chemical Property of (R)-2-(methoxycarbonylamino)-3-phenylpropanoic acid

Chemical Property:

• Boiling Point: 409.9±38.0 °C(Predicted)
• PKA: 4.32±0.10(Predicted)
• PSA: 79.12000
• Density: 1.246±0.06 g/cm3(Predicted)
• LogP: 1.24270

Purity/Quality:

≥95% ^*data from raw suppliers

(R)-2-(methoxycarbonylamino)-3-phenylpropanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-(methoxycarbonylamino)-3-phenylpropanoic acid

There total 7 articles about (R)-2-(methoxycarbonylamino)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methoxycarbonyl-D-phenylalanine-p-nitrophenyl ester (1243-60-3) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (R)-N-(methoxycarbonyl)phenylalanine (67401-65-4)

Guidance literature:

With cetyltrimethylammonim bromide; Dec-L-His; In acetonitrile; at 25 ℃; Rate constant; 0.02M phosphate buffer, pH=7.3; other catalyst and surfactant concentrations; variation of catalysts and surfactants;

Reference yield:

D-(R)-phenylalanine (673-06-3,25191-15-5,658-69-5,67675-33-6) + methyl chloroformate (79-22-1) → (R)-N-(methoxycarbonyl)phenylalanine (67401-65-4)

Guidance literature:

With sodium hydroxide; sodium carbonate; for 1h;

DOI:10.1021/jo00164a009

Reference yield:

Methyl-(Z)-α-acetamidocinnamate → (R)-N-(methoxycarbonyl)phenylalanine (67401-65-4) + N-methoxycarbonyl-L-phenylalanine (41844-91-1)

Guidance literature:

With hydrogen; Rh{(-)-2,4-bis(Ph₂P)pentane}(2,5-norbornadiene)ClO₄; In methanol; at 25 ℃; under 760 Torr; Further Variations:; Reagents; Solvents; Kinetics; Product distribution;

DOI:10.1002/(SICI)1521-3765(20000103)6:1<139::AID-CHEM139>3.0.CO;2-U

upstream raw materials:

N-Methoxycarbonylphenylalanin-p-nitrophenylester

N-methoxycarbonyl-D-phenylalanine-p-nitrophenyl ester

D-(R)-phenylalanine

methyl chloroformate

Downstream raw materials:

((R)-1-Chlorocarbonyl-2-phenyl-ethyl)-carbamic acid methyl ester

(R)-N-methoxy-2-(methoxycarbonylamino)-3-phenylpropanamide

(R)-(5-amino-2,3-dihydro-1H-inden-2-yl)carbamic acid methyl ester

(R)-1,2,3,4-tetrahydro-N-methyl-3-quinolinamine