(S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid

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Chemical Name:(S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid
CAS No.:1448165-50-1
Molecular Formula:C₄₄H₆₄N₁₃O₁₃P
Molecular Weight:1014.05
Hs Code.:

(S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid

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Chemical Property of (S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid

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Technology Process of (S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid

There total 4 articles about (S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₈H₇₆N₁₃O₁₃P

: 1448165-50-1
(S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In water; for 1h;
DOI:10.1002/chem.201301478

Reference yield:

: C₄₀H₅₆N₁₀O₁₁

: 1448165-50-1
(S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid; chlorotriisopropylsilane / water / 1 h

2: copper(ll) sulfate pentahydrate; copper / water; tert-butyl alcohol / 16 h / 20 °C

3: trifluoroacetic acid; chlorotriisopropylsilane / water / 1 h

With copper(ll) sulfate pentahydrate; chlorotriisopropylsilane; copper; trifluoroacetic acid; In water; tert-butyl alcohol;
DOI:10.1002/chem.201301478

Reference yield:

: C₂₅H₃₃N₂O₇P

: 1448165-50-1
(S)-2-(4-(3-(5-(4-(((S)-2-acetamido-6-(3-phosphonopropanamido)hexanamido)-methyl)-1H-1,2,3-triazol-1-yl)pentanamido)propoxy)-2,6-dimethylbenzamido)-3-(2-(3-guanidinobenzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: HATU; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: copper(ll) sulfate pentahydrate; copper / water; tert-butyl alcohol / 16 h / 20 °C

3: trifluoroacetic acid; chlorotriisopropylsilane / water / 1 h

With 1-hydroxy-7-aza-benzotriazole; copper(ll) sulfate pentahydrate; chlorotriisopropylsilane; copper; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/chem.201301478