1-Benzyl-6-chloro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

Base Information

• Chemical Name: 1-Benzyl-6-chloro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile
• CAS No.: 70357-64-1
• Molecular Formula: C₁₅H₁₀ClN₃
• Molecular Weight: 267.717
• European Community (EC) Number: 850-701-8
• Mol file: 70357-64-1.mol

Synonyms:1-Benzyl-6-chloro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile;70357-64-1;1-benzyl-6-chloropyrrolo[3,2-c]pyridine-7-carbonitrile;TQP0469;1-benzyl-6-chloro-7-cyano-5-azaindole;EN300-7504652

Chemical Property of 1-Benzyl-6-chloro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 267.0563250
• Heavy Atom Count: 19
• Complexity: 358

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN2C=CC3=CN=C(C(=C32)C#N)Cl

Technology Process of 1-Benzyl-6-chloro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

There total 2 articles about 1-Benzyl-6-chloro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-6-chloro-7-cyano-5-azaindoline (66751-32-4) → 1-Benzyl-6-chloro-7-cyano-5-azaindole (70357-64-1)

Guidance literature:

With manganese(IV) oxide; In tetrachloromethane;

DOI:10.1007/BF00507248

Reference yield:

→ 1-Benzyl-6-chloro-7-cyano-5-azaindole (70357-64-1)

Guidance literature:

Azaindolin (If), MnO2;

DOI:10.1007/BF00474099

Reference yield: 85.0%

1-Benzyl-6-chloro-7-cyano-5-azaindole (70357-64-1) → 1-benzyl-6-chloro-7-aminocarbonyl-5-azaindole (74976-30-0)

Guidance literature:

With sodium hydroxide; for 17h; Heating;

DOI:10.1007/BF00777399

upstream raw materials:

1-benzyl-6-chloro-7-cyano-5-azaindoline

Downstream raw materials:

1-Benzyl-6-(3-isopropyl-2-phenyl-oxazolidin-5-ylmethoxy)-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

1-benzyl-6-chloro-7-aminocarbonyl-5-azaindole