2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester

Base Information

• Chemical Name: 2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester
• CAS No.: 473710-43-9
• Molecular Formula: C₅₀H₇₉N₅O₁₃Si₂
• Molecular Weight: 1014.37

Synonyms:

Chemical Property of 2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester

There total 6 articles about 2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(dibenzylamino)ethanoate (94226-56-9) → 2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester (473710-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 14 percent / tetrahydrofuran / 17 h / -78 - -35 °C

2.1: H₂ / 10 percent Pd/C / methanol

3.1: NaBH(OAc)3; AcOH / tetrahydrofuran

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(03)00671-1

Reference yield:

2',3'-O-bis(tert-butyldimethylsilyl)-3-N-(p-methoxybenzyl)uridine-5'-aldehyde (137233-53-5) → 2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester (473710-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 14 percent / tetrahydrofuran / 17 h / -78 - -35 °C

2.1: H₂ / 10 percent Pd/C / methanol

3.1: NaBH(OAc)3; AcOH / tetrahydrofuran

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(03)00671-1

Reference yield:

(2S,3S)-3-{(2R,3R,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-2-dibenzylamino-3-hydroxy-propionic acid tert-butyl ester (473709-90-9) → 2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester (473710-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / methanol

2: NaBH(OAc)3; AcOH / tetrahydrofuran

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(03)00671-1

upstream raw materials:

[(1S,2S)-2-Hydroxy-1-(3-oxo-propylcarbamoyl)-propyl]-carbamic acid benzyl ester

(2S,3S)-2-Amino-3-{(2R,3R,4R,5R)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester

(2S,3S)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoic acid

tert-butyl 2-(dibenzylamino)ethanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 473710-43-9 2-[3-(2-benzyloxycarbonylamino-3-hydroxy-butyrylamino)-propylamino]-3-{3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-yl}-3-hydroxy-propionic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send