(2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate

Base Information

Chemical Name:(2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate
CAS No.:1032765-59-5
Molecular Formula:C₂HF₃O₂*C₂₄H₄₄N₄O₄
Molecular Weight:566.662
Hs Code.:

(2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate

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Chemical Property of (2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate

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Technology Process of (2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate

There total 5 articles about (2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127095-92-5
N-tert-butoxycarbonyl-D-cyclohexylalanine

: 1032765-59-5
(2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 14 h / 20 °C

2.1: triethylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 80 °C

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 10 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm501840b

Reference yield:

: 1032767-71-7
(R)-2-amino-3-cyclohexylpropanoic acid trifluoroacetate

: 1032765-59-5
(2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 80 °C

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

3.1: dichloromethane / 10 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm501840b