1-(2-aminoacetyl)-4-methoxy-7-nitroindoline hydrochloride

Base Information

• Chemical Name: 1-(2-aminoacetyl)-4-methoxy-7-nitroindoline hydrochloride
• CAS No.: 1316316-45-6
• Molecular Formula: C₁₁H₁₃N₃O₄*ClH
• Molecular Weight: 287.703
• Mol file: 1316316-45-6.mol

Synonyms:

Chemical Property of 1-(2-aminoacetyl)-4-methoxy-7-nitroindoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-aminoacetyl)-4-methoxy-7-nitroindoline hydrochloride

There total 6 articles about 1-(2-aminoacetyl)-4-methoxy-7-nitroindoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-(2-aminoacetyl)-4-methoxy-7-nitroindoline (1316890-48-8) → 1-(2-aminoacetyl)-4-methoxy-7-nitroindoline hydrochloride (1316316-45-6)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; pH=6.68;

DOI:10.1016/j.tet.2011.05.045

Reference yield:

4-methoxy-1H-indole (4837-90-5) → 1-(2-aminoacetyl)-4-methoxy-7-nitroindoline hydrochloride (1316316-45-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium cyanoborohydride; acetic acid

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C

4.1: sodium nitrate; acetic anhydride; scandium tris(trifluoromethanesulfonate) / acetonitrile / 22 h / 20 °C

5.1: triphenylphosphine / water; N,N-dimethyl-formamide / 20 °C

5.2: 20 °C / pH 1.3

5.3: pH 10.5

6.1: hydrogenchloride / methanol; water / 20 °C / pH 6.68

With hydrogenchloride; sodium nitrate; sodium azide; acetic anhydride; sodium cyanoborohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; scandium tris(trifluoromethanesulfonate); In methanol; water; N,N-dimethyl-formamide; acetonitrile; 5.1: Staudinger reaction / 5.2: Staudinger reaction;

DOI:10.1016/j.tet.2011.05.045

Reference yield:

1-(2-bromoacetyl)-4-methoxyindoline (1316316-42-3) → 1-(2-aminoacetyl)-4-methoxy-7-nitroindoline hydrochloride (1316316-45-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 °C

2.1: sodium nitrate; acetic anhydride; scandium tris(trifluoromethanesulfonate) / acetonitrile / 22 h / 20 °C

3.1: triphenylphosphine / water; N,N-dimethyl-formamide / 20 °C

3.2: 20 °C / pH 1.3

3.3: pH 10.5

4.1: hydrogenchloride / methanol; water / 20 °C / pH 6.68

With hydrogenchloride; sodium nitrate; sodium azide; acetic anhydride; triphenylphosphine; scandium tris(trifluoromethanesulfonate); In methanol; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Staudinger reaction / 3.2: Staudinger reaction;

DOI:10.1016/j.tet.2011.05.045

upstream raw materials:

4-methoxy-1H-indole

1-(2-bromoacetyl)-4-methoxyindoline

1-(2-azidoacetyl)-4-methoxyindoline

1-(2-azidoacetyl)-4-methoxy-7-nitroindoline