2,3-diphenyl-succinic anhydride

Base Information

• Chemical Name: 2,3-diphenyl-succinic anhydride
• CAS No.: 17325-43-8
• Molecular Formula: C₁₆H₁₂O₃
• Molecular Weight: 252.269
• Mol file: 17325-43-8.mol

Synonyms:

Chemical Property of 2,3-diphenyl-succinic anhydride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-diphenyl-succinic anhydride

There total 5 articles about 2,3-diphenyl-succinic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S,3S)-(+)-2,3-Diphenylsuccinic acid (74431-38-2) → 2,3-diphenyl-succinic anhydride (5465-38-3,17325-42-7,17325-43-8,54282-54-1,101278-21-1)

Guidance literature:

With acetyl chloride; for 16h; Inert atmosphere; Reflux;

DOI:10.1039/c8cc00609a

Reference yield:

Ethyl 2-phenylethanoate (101-97-3) → 2,3-diphenyl-succinic anhydride (5465-38-3,17325-42-7,17325-43-8,54282-54-1,101278-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -15 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: potassium hydroxide / water; ethanol / 16 h / Reflux

2.2: 20 °C / pH 1

3.1: acetyl chloride / 16 h / Inert atmosphere; Reflux

With potassium tert-butylate; acetyl chloride; potassium hydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1039/c8cc00609a

Reference yield:

diethyl 2,3-diphenylsuccinate → 2,3-diphenyl-succinic anhydride (5465-38-3,17325-42-7,17325-43-8,54282-54-1,101278-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / water; ethanol / 16 h / Reflux

1.2: 20 °C / pH 1

2.1: acetyl chloride / 16 h / Inert atmosphere; Reflux

With acetyl chloride; potassium hydroxide; In ethanol; water;

DOI:10.1039/c8cc00609a

upstream raw materials:

Ethyl 2-phenylethanoate

(2S,3S)-(+)-2,3-Diphenylsuccinic acid

phenylacetic acid

Downstream raw materials:

(2R,3R)-(-)-2,3-diphenylbutane

(2R,3R)-2,3-diphenyl-1,4-butandiol-di-p-tosylat

(-)-(2R,3R)-2,3-diphenyl-1,4-butanediol