Technology Process of C49H51N7O6
There total 8 articles about C49H51N7O6 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 3 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; water; ethanol / 2 h / 100 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); potassium acetate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; ethanol; dichloromethane; water; toluene;
3: |Suzuki-Miyaura Coupling;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; water; ethanol / 2 h / 100 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); potassium acetate; sodium carbonate;
In
1,4-dioxane; ethanol; water; toluene;
2: |Suzuki-Miyaura Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1.17 h / 0 °C / Reflux
2: sodium hydroxide / tetrahydrofuran; water / 1 h / 25 °C
3: sodium carbonate / tetrahydrofuran; water / 2 h / Reflux
4: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; water; ethanol / 2 h / 100 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; sodium carbonate; N,N-dimethyl-formamide; sodium hydroxide;
In
tetrahydrofuran; ethanol; water; toluene;
4: |Suzuki-Miyaura Coupling;