N-[4-methoxy-3-[[[(2S,3S)-2-phenylpiperidin-3-yl]amino]methyl]phenyl]-N-methylmethanesulfonamide

Base Information

Chemical Name:N-[4-methoxy-3-[[[(2S,3S)-2-phenylpiperidin-3-yl]amino]methyl]phenyl]-N-methylmethanesulfonamide
CAS No.:182822-62-4
Molecular Formula:C21H29N3O3S
Molecular Weight:403.544
Hs Code.:
DSSTox Substance ID:DTXSID50438758
Nikkaji Number:J1.589.155F
Wikidata:Q82254580
Pharos Ligand ID:DNXPKJJNFWFU
ChEMBL ID:CHEMBL329007
Mol file:182822-62-4.mol

Synonyms:182822-62-4;CP 141938;CP-141938;CHEMBL329007;N-[4-methoxy-3-[[[(2S,3S)-2-phenylpiperidin-3-yl]amino]methyl]phenyl]-N-methylmethanesulfonamide;SCHEMBL7820136;DTXSID50438758;GZLOIBNBDUHEFY-FPOVZHCZSA-N;160503-02-6;BDBM50069863;N-{4-Methoxy-3-[((2S,3S)-2-phenyl-piperidin-3-ylamino)-methyl]-phenyl}-N-methyl-methanesulfonamide

Suppliers and Price of N-[4-methoxy-3-[[[(2S,3S)-2-phenylpiperidin-3-yl]amino]methyl]phenyl]-N-methylmethanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CP-141938
5mg
$ 730.00

American Custom Chemicals Corporation
CP-141938 95.00%
10MG
$ 7230.30

Total 7 raw suppliers

Chemical Property of N-[4-methoxy-3-[[[(2S,3S)-2-phenylpiperidin-3-yl]amino]methyl]phenyl]-N-methylmethanesulfonamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:580.718°C at 760 mmHg
Flash Point:305.007°C
PSA：79.05000
Density:1.239g/cm³
LogP:4.47440
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:403.19296297
Heavy Atom Count:28
Complexity:574

Purity/Quality:

99% ^*data from raw suppliers

CP-141938 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C1=CC(=C(C=C1)OC)CNC2CCCNC2C3=CC=CC=C3)S(=O)(=O)C
Isomeric SMILES:CN(C1=CC(=C(C=C1)OC)CN[C@H]2CCCN[C@H]2C3=CC=CC=C3)S(=O)(=O)C
Uses CP-122721 and CP-141938 are potent and selective neurokinin-1 (NK1) receptor antagonists with very different brain disposition and potency in models of centrally mediated activity.

Technology Process of N-[4-methoxy-3-[[[(2S,3S)-2-phenylpiperidin-3-yl]amino]methyl]phenyl]-N-methylmethanesulfonamide

There total 3 articles about N-[4-methoxy-3-[[[(2S,3S)-2-phenylpiperidin-3-yl]amino]methyl]phenyl]-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136982-36-0
(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine

: 182822-62-4
(2S,3S)-3-[2-methoxy-5-(N-methyl-N-methanesulfonylamino)-benzyl]amino-2-phenylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / PtO₂

2: NaCHBH₃ / methanol

With hydrogen; sodium cyanoborohydride; platinum(IV) oxide; In methanol;
DOI:10.1016/S0960-894X(98)00012-2