GNE 477

Base Information

• Chemical Name: GNE 477
• CAS No.: 1032754-81-6
• Molecular Formula: C21H28N8O3S2
• Molecular Weight: 504.63
• Mol file: 1032754-81-6.mol

Synonyms:GNE-477;UNII-0E8LA9H0RY;

Chemical Property of GNE 477

Chemical Property:

• PKA: 4.22±0.10(Predicted)
• PSA: 168.02000
• Density: 1.51±0.1 g/cm3(Predicted)
• LogP: 1.90440
• Solubility.: insoluble in H2O; insoluble in EtOH; ≥16.69 mg/mL in DMSO with gentle warming

Purity/Quality:

98%min ^*data from raw suppliers

5-(7-Methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GNE 477

There total 2 articles about GNE 477 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ GNE-477 (1032754-81-6)

Guidance literature:

Reference yield:

5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine (402960-38-7) + 2-chloro-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (1032757-88-2) → GNE-477 (1032754-81-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In water; acetonitrile; at 150 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.bmcl.2010.03.046

upstream raw materials:

5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

2-chloro-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Refernces

• 1、 -. "PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE". Page/Page column 168. . Retrieved 2008/12/06.