Technology Process of Abexinostat
There total 7 articles about Abexinostat which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine; acetic acid;
In
methanol;
at 35 - 40 ℃;
for 0.5h;
pH=7;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 5 h / 90 - 100 °C
2.1: hydrogenchloride / ethyl acetate / 45 - 55 °C
3.1: triethylamine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate / tetrahydrofuran / 0.5 h / -5 - 0 °C / Inert atmosphere
3.2: 5 h / 40 - 45 °C / Inert atmosphere
4.1: hydroxylamine; acetic acid / methanol / 0.5 h / 35 - 40 °C / pH 7
With
hydrogenchloride; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; hydroxylamine; potassium carbonate; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / ethyl acetate / 45 - 55 °C
2.1: triethylamine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate / tetrahydrofuran / 0.5 h / -5 - 0 °C / Inert atmosphere
2.2: 5 h / 40 - 45 °C / Inert atmosphere
3.1: hydroxylamine; acetic acid / methanol / 0.5 h / 35 - 40 °C / pH 7
With
hydrogenchloride; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; hydroxylamine; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; ethyl acetate;
