UNC0321

Base Information

• Chemical Name: UNC0321
• CAS No.: 1238673-32-9
• Molecular Formula: C27H45N7O3
• Molecular Weight: 515.69
• Mol file: 1238673-32-9.mol

Synonyms:UNC0321;UNC0321(UNC-0321);UNC 0321; UNC-0321; UNC0321; UNC-0321;7-(2-(2-(diMethylaMino)ethoxy)ethoxy)-6-Methoxy-2-(4-Methyl-1,4-diazepan-1-yl)-N-(1-Methylpiperidin-4-yl)quinazolin-4-aMine;7-[2-[2-(Dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine;4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-

Chemical Property of UNC0321

Chemical Property:

• Boiling Point: 664.7±65.0 °C(Predicted)
• PKA: 9.34±0.70(Predicted)
• PSA: 81.69000
• Density: 1.150±0.06 g/cm3(Predicted)
• LogP: 1.60610

Purity/Quality:

98% min ^*data from raw suppliers

UNC0321 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of UNC0321

There total 1 articles about UNC0321 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) + 6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-(1-methylpiperidin-4-ylamino)quinazolin-7-ol (1238673-02-3) → 7-(2-(2-(dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine (1238673-32-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm100478y

upstream raw materials:

1-O-Dimethylaminoethyl-ethylenglykol

6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-(1-methylpiperidin-4-ylamino)quinazolin-7-ol

Refernces