1-amino-5(S)-<-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(S),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane

Base Information

Chemical Name:1-amino-5(S)-<-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(S),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane
CAS No.:110613-66-6
Molecular Formula:C₃₇H₅₉N₇O₇
Molecular Weight:713.918
Hs Code.:

1-amino-5(S)-<<N-<(tert-butyloxy)carbonyl>-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(S),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane

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Chemical Property of 1-amino-5(S)-<-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(S),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane

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Technology Process of 1-amino-5(S)-<-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(S),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane

There total 13 articles about 1-amino-5(S)-<-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(S),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: N--L-phenylalanyl-L-histidyl>-5(S)-amino-1-azido-6-cyclohexyl-2(R),4(S)-dihydroxy-2-(isobutylcarbamoyl)hexane

: 110613-66-6,110660-45-2
1-amino-5(S)-<-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(R),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In methanol; for 16h;
DOI:10.1021/jm00394a008

Reference yield: 76.0%

: (2S,4S,5S)-5-Amino-2-azidomethyl-6-cyclohexyl-2,4-dihydroxy-hexanoic acid isobutyl-amide; hydrochloride

: 110613-66-6,110660-45-2
1-amino-5(S)-<-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(S),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In methanol; for 16h;
DOI:10.1021/jm00394a008

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 110613-66-6,110660-45-2
1-amino-5(S)-<-L-phenylalanyl-L-histidyl>amino>-6-cyclohexyl-2(R),4(S)-dihydroxy-2-(N-isobutylcarbamoyl)hexane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-butyllithium, 2.) ClTi(O-iPr)3

2: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

3: 98 percent / NaN₃, NH₄Cl / methanol / 18 h / Heating

4: HCl(g) / dioxane / 1 h / Ambient temperature

5: 72 percent / 1-hydroxybenzotriazole*H₂O, 4-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide*HCl / dimethylformamide / -23 - 20 °C

6: 88 percent / H₂, CH₃COOH / 10percent Pd/C / methanol / 16 h

With 4-methyl-morpholine; triisopropoxytitanium(IV) chloride; hydrogenchloride; n-butyllithium; sodium azide; hydrogen; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a008