o-(S)-(2-methylbutoxy)phenyl bromide

Base Information

• Chemical Name: o-(S)-(2-methylbutoxy)phenyl bromide
• CAS No.: 131759-35-8
• Molecular Formula: C₁₁H₁₅BrO
• Molecular Weight: 243.143
• Mol file: 131759-35-8.mol

Synonyms:

Chemical Property of o-(S)-(2-methylbutoxy)phenyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-(S)-(2-methylbutoxy)phenyl bromide

There total 3 articles about o-(S)-(2-methylbutoxy)phenyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(2S)-2-methyl-1-butanol (1565-80-6) + 2-hydroxybromobenzene (95-56-7) → o-(S)-(2-methylbutoxy)phenyl bromide (131759-35-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 70 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.202014130

Reference yield:

(2S)-2-methyl-1-butanol (1565-80-6) → o-(S)-(2-methylbutoxy)phenyl bromide (131759-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / triphenyl phosphite, iodine / CH₂Cl₂ / 1.) 0 degC, 2 h 2.) rt, 1 h

2: 1.) NaOH / 1.) aq. EtOH, reflux, 20 min 2.) aq. EtOH, reflux, 10 h

With triphenyl phosphite; sodium hydroxide; iodine; In dichloromethane;

DOI:10.1021/jo00002a056

Reference yield:

(S)-1-iodo-2-methyl-butane (29394-58-9) + 2-hydroxybromobenzene (95-56-7) → o-(S)-(2-methylbutoxy)phenyl bromide (131759-35-8)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction; 1.) aq. EtOH, reflux, 20 min 2.) aq. EtOH, reflux, 10 h;

DOI:10.1021/jo00002a056

upstream raw materials:

(S)-1-iodo-2-methyl-butane

2-hydroxybromobenzene

(2S)-2-methyl-1-butanol

Downstream raw materials:

(-)-(2S,3R)-3--1,2-benzisothiazole 1,1-dioxide oxide

(+)-(2R,3S)-3--1,2-benzisothiazole 1,1-dioxide oxide

(+)-3--1,2-benzisothiazole 1,1-dioxide