N¹-<<3-<3-1-(spermidino)succinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tetra(trifluoroacetate)

Base Information

• Chemical Name: N¹-<<3-<3-1-(spermidino)succinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tetra(trifluoroacetate)
• CAS No.: 133765-78-3
• Molecular Formula: 4C₂HF₃O₂*C₃₂H₅₀N₈O₄
• Molecular Weight: 1066.9

Synonyms:

Chemical Property of N¹-<<3-<3-1-(spermidino)succinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tetra(trifluoroacetate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-<<3-<3-1-(spermidino)succinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tetra(trifluoroacetate)

There total 5 articles about N¹-<<3-<3-1-(spermidino)succinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tetra(trifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N1-<<3-<3-4,N8-bis(tert-butoxycarbonyl)spermidinosuccinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>-N4,N8-bis(tert-butoxycarbonyl)spermidine (133765-76-1) + trifluoroacetic acid (76-05-1) → N1-<<3-<3-1-(spermidino)succinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tetra(trifluoroacetate) (133765-78-3)

Guidance literature:

for 0.25h;

DOI:10.1016/0223-5234(91)90058-U

Reference yield:

N1-<<3-(3-nitrobenzene-1-carboxamido)benzen-1-yl>carbonyl>-N4,N8-bis(tert-butoxycarbonyl)spermidine (133765-72-7) → N1-<<3-<3-1-(spermidino)succinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tetra(trifluoroacetate) (133765-78-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr / Ambient temperature

2: 85 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 2 h / Ambient temperature

3: 49 percent / benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP) / acetonitrile / 2 h / Ambient temperature

4: 98 percent / 0.25 h

With dmap; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/0223-5234(91)90058-U

Reference yield:

m-nitrobenzoic acid chloride (121-90-4) → N1-<<3-<3-1-(spermidino)succinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tetra(trifluoroacetate) (133765-78-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / pyridine / acetonitrile / 1 h / Ambient temperature

2: 95 percent / H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr / Ambient temperature

3: 85 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 2 h / Ambient temperature

4: 49 percent / benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP) / acetonitrile / 2 h / Ambient temperature

5: 98 percent / 0.25 h

With pyridine; dmap; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/0223-5234(91)90058-U

upstream raw materials:

N¹-<<3-<3-4,N⁸-bis(tert-butoxycarbonyl)spermidinosuccinamido>benzene-1-carboxamido>benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine

trifluoroacetic acid

N¹-<<3-(3-aminobenzene-1-carboxamido)benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine

N¹-<<3-(3-nitrobenzene-1-carboxamido)benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine

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