Chemical Property of 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Chemical Property:
- PSA：105.51000
- LogP:3.99040
- Storage Temp.:?20°C
- Solubility.:DMSO: soluble10mg/mL, clear (warmed)
- XLogP3:2.6
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:7
- Exact Mass:366.16919058
- Heavy Atom Count:27
- Complexity:433
- Purity/Quality:
-
99%, *data from raw suppliers
GW 2580
*data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,Xi
- Hazard Codes:Xn,Xi
- Statements:
22-36/37/38
- Safety Statements:
26-36/37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
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Description
GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 μM)1. GW-2580 completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. GW-2580 abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo.
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Uses
GW2580 has been used to study its effect on paracrine signaling from stretched cardiomyocyte on cardiac fibroblast phenotype.
