4(3H)-Pyrimidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-methoxyphenyl)cyclopropyl]methyl]thio]-5-methyl-

Base Information

Chemical Name:4(3H)-Pyrimidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-methoxyphenyl)cyclopropyl]methyl]thio]-5-methyl-
CAS No.:1114507-62-8
Molecular Formula:C₂₄H₂₄F₂N₂O₂S
Molecular Weight:442.53
Hs Code.:

Synonyms:6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[(1R,2R)-2-(4-methoxyphenyl)cyclopropyl]methylsulfanyl]-5-methyl-1H-pyrimidin-4-one;4(3H)-PyriMidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-Methoxyphenyl)cyclopropyl]Methyl]thio]-5-Methyl-

Suppliers and Price of 4(3H)-Pyrimidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-methoxyphenyl)cyclopropyl]methyl]thio]-5-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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American Custom Chemicals Corporation
6-[(1R)-1-(2,6-DIFLUOROPHENYL)ETHYL]-2-[[[(1R,2R)-2-(4-METHOXYPHENYL)CYCLOPROPYL]METHYL]THIO]-5-METHYL-4(3H)PYRIMIDINONE 95.00%
5MG
$ 504.53

Total 2 raw suppliers

Chemical Property of 4(3H)-Pyrimidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-methoxyphenyl)cyclopropyl]methyl]thio]-5-methyl-

Chemical Property:

PSA：80.54000
LogP:5.82500

Purity/Quality:

99% ^*data from raw suppliers

6-[(1R)-1-(2,6-DIFLUOROPHENYL)ETHYL]-2-[[[(1R,2R)-2-(4-METHOXYPHENYL)CYCLOPROPYL]METHYL]THIO]-5-METHYL-4(3H)PYRIMIDINONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4(3H)-Pyrimidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-methoxyphenyl)cyclopropyl]methyl]thio]-5-methyl-

There total 1 articles about 4(3H)-Pyrimidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-methoxyphenyl)cyclopropyl]methyl]thio]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 255898-86-3
6-(1-(2,6-difluorophenyl)ethyl)-5-methyl-3,4-dihydro-2-thioxopyrimidin-4(3H)-one

: 173831-51-1
(-)-(1R,2R)-2-(p-methoxyphenyl)cyclopropylmethanol

: 1114507-62-8
6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[(1R,2R)-2-(4-methoxyphenyl)cyclopropylmethylsulfanyl]-5-methyl-3H-pyrimidin-4-one

: 1114507-65-1
6-[(1S)-1-(2,6-difluorophenyl)ethyl]-2-[(1R,2R)-2-(4-methoxyphenyl)cyclopropylmethylsulfanyl]-5-methyl-3H-pyrimidin-4-one

Guidance literature:: With di-isopropyl azodicarboxylate; trimethylphosphane; In N,N-dimethyl-formamide; toluene; at 40 ℃; for 0.166667h; optical yield given as %de; Inert atmosphere; Microwave irradiation; Cooling with ice;
DOI:10.1021/jm801330n