1H-Imidazole, 1-[(4-chlorophenyl)phenyl[4-(1-pyrrolidinylmethyl)phenyl]methyl]-

Base Information

Chemical Name:1H-Imidazole, 1-[(4-chlorophenyl)phenyl[4-(1-pyrrolidinylmethyl)phenyl]methyl]-
CAS No.:927689-99-4
Molecular Formula:C₂₇H₂₆ClN₃
Molecular Weight:427.977
Hs Code.:

Synonyms:1-[(4-chlorophenyl)-phenyl-[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]imidazole;1H-IMidazole, 1-[(4-chlorophenyl)phenyl[4-(1-pyrrolidinylMethyl)phenyl]Methyl]-

Suppliers and Price of 1H-Imidazole, 1-[(4-chlorophenyl)phenyl[4-(1-pyrrolidinylmethyl)phenyl]methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-[(4-CHLOROPHENYL)PHENYL-[4-(1-PYRROLIDINYLMETHYL)PHENYL]METHYL]-1H-IMIDAZOLE 95.00%
5MG
$ 499.58

Total 4 raw suppliers

Chemical Property of 1H-Imidazole, 1-[(4-chlorophenyl)phenyl[4-(1-pyrrolidinylmethyl)phenyl]methyl]-

Chemical Property:

PSA：21.06000
LogP:5.91040

Purity/Quality:

99% ^*data from raw suppliers

1-[(4-CHLOROPHENYL)PHENYL-[4-(1-PYRROLIDINYLMETHYL)PHENYL]METHYL]-1H-IMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole, 1-[(4-chlorophenyl)phenyl[4-(1-pyrrolidinylmethyl)phenyl]methyl]-

There total 8 articles about 1H-Imidazole, 1-[(4-chlorophenyl)phenyl[4-(1-pyrrolidinylmethyl)phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 927689-99-4
1-((4-chlorophenyl)(phenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methyl)-1H-imidazole

Guidance literature:

Reference yield:

: 288-32-4
1H-imidazole

: 1-{4-[chloro-(4-chloro-phenyl)-phenyl-methyl]-benzyl}-pyrrolidine; hydrochloride

: 927689-99-4
1-((4-chlorophenyl)(phenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methyl)-1H-imidazole

Guidance literature:: With triethylamine; In acetonitrile; at 80 ℃; for 4h;
DOI:10.1021/jm061429p

Reference yield:

: 742085-16-1
(4-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanone

: 927689-99-4
1-((4-chlorophenyl)(phenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: 76 percent / tetrahydrofuran / 8 h / 75 °C

2.1: SOCl₂; DMF / CH₂Cl₂ / 4.33 h / 0 - 45 °C

3.1: 450 mg / Et₃N / acetonitrile / 4 h / 80 °C

With thionyl chloride; iodine; magnesium; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetonitrile; 1.2: Grignard reaction;
DOI:10.1021/jm061429p