2,2,2-trifluoroethanethioamide

Base Information

• Chemical Name: 2,2,2-trifluoroethanethioamide
• CAS No.: 421-52-3
• Molecular Formula: C2H2 F3 N S
• Molecular Weight: 129.106
• Hs Code.: 2930909090
• Mol file: 421-52-3.mol

Synonyms:Acetamide,2,2,2-trifluorothio- (6CI,8CI);2,2,2-Trifluorothioacetamide;NSC 381430;Trifluorothioacetamide;

Chemical Property of 2,2,2-trifluoroethanethioamide

Chemical Property:

• Vapor Pressure: 31.5mmHg at 25°C
• Melting Point: 42-43 °C(Solv: ethyl ether (60-29-7))
• Refractive Index: 1.434
• Boiling Point: 104°Cat760mmHg
• PKA: 11.02±0.29(Predicted)
• Flash Point: 16.7°C
• PSA: 58.11000
• Density: 1.49g/cm³
• LogP: 1.53510
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

2,2,2-Trifluorothioacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-trifluoroethanethioamide

There total 6 articles about 2,2,2-trifluoroethanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2,2-trifluoroacetamide (354-38-1) → trifluorothioacetamide (421-52-3)

Guidance literature:

With tetraphosphorus decasulfide; In tetrahydrofuran; at 70 - 75 ℃; for 4h; Inert atmosphere;

Reference yield: 84.0%

Lawessons reagent (19172-47-5,94367-93-8) + 2,2,2-trifluoroacetamide (354-38-1) → trifluorothioacetamide (421-52-3)

Guidance literature:

Reference yield:

trifluoroacetonitrile (353-85-5) → trifluorothioacetamide (421-52-3)

Guidance literature:

With hydrogen sulfide;

DOI:10.1021/ja01604a021

upstream raw materials:

trifluoroacetonitrile

2,2,2-trifluoroacetamide

Lawessons reagent

trifluoromethylhydrazine

Downstream raw materials:

N-benzyl-2,2,2-trifluoroacetamide

4,5-diphenyl-2-trifluoromethyl-thiazole

4,5-bis-(4-chloro-phenyl)-2-trifluoromethyl-thiazole

4,5 bis(4 methoxyphenyl) 2 (trifluoromethyl)thiazole