Technology Process of 5-Chloro-2-[(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl]-1,3-benzoxazole
There total 73 articles about 5-Chloro-2-[(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl]-1,3-benzoxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C13H16ClN3O*C18H14O8;
With
sodium hydroxide;
In
dichloromethane; water;
at 20 ℃;
for 1h;
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid;
With
oxalyl dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 0 - 10 ℃;
for 1h;
5-chloro-2-[(5R)-hexahydro-5-methyl-1H-1,4-diazepin-1-yl]benzoxazole;
With
triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 0 - 15 ℃;
for 1h;
optical yield given as %ee;
DOI:10.1021/op1002853
- Guidance literature:
-
5-methyl-2-(1H-1,2,3-triazol-2-yl)benzoic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 10 ℃;
for 1h;
5-chloro-2-[(5R)-hexahydro-5-methyl-1H-1,4-diazepin-1-yl]benzoxazole;
With
triethylamine;
In
dichloromethane;
at -10 - -5 ℃;
for 1h;
- Guidance literature:
-
With
4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
DOI:10.1016/j.tetlet.2021.153014
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