Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[2-[[(4-chlorophenyl)amino]carbonyl]-4-methylphenyl]-

Base Information

• Chemical Name: Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[2-[[(4-chlorophenyl)amino]carbonyl]-4-methylphenyl]-
• CAS No.: 229339-09-7
• Molecular Formula: C23H16Cl2N2O2S
• Molecular Weight: 455.36
• Mol file: 229339-09-7.mol

Synonyms:3-chloro-N-[2-[(4-chlorophenyl)carbamoyl]-4-methylphenyl]-1-benzothiophene-2-carboxamide;Benzo[b]thiophene-2-carboxaMide, 3-chloro-N-[2-[[(4-chlorophenyl)aMino]carbonyl]-4-Methylphenyl]-

Chemical Property of Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[2-[[(4-chlorophenyl)amino]carbonyl]-4-methylphenyl]-

Chemical Property:

• PSA: 89.93000
• LogP: 7.47810

Purity/Quality:

99% ^*data from raw suppliers

3-CHLORO-N-[2-[[(4-CHLOROPHENYL)AMINO]CARBONYL]-4-METHYLPHENYL]BENZO[B]THIOPHENE-2-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[2-[[(4-chlorophenyl)amino]carbonyl]-4-methylphenyl]-

There total 8 articles about Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[2-[[(4-chlorophenyl)amino]carbonyl]-4-methylphenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-chlorobenzo[b]thiophen-2-carbonyl chloride (21815-91-8) → N-(4-chlorophenyl)-2-[((3-chlorobenzo[b]thien-2-yl)carbonyl)amino]-5-methylbenzamide (229339-09-7)

Guidance literature:

In pyridine;

Reference yield:

5-methyl-2-nitrobenzoic acid (3113-72-2) → N-(4-chlorophenyl)-2-[((3-chlorobenzo[b]thien-2-yl)carbonyl)amino]-5-methylbenzamide (229339-09-7)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂; DMF / CH₂Cl₂ / 20 °C

2: NEt₃ / CH₂Cl₂ / 20 °C

3: SnCl₂*2H₂O / ethyl acetate / Heating

4: pyridine / 0 - 20 °C

With pyridine; thionyl chloride; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In dichloromethane; ethyl acetate;

DOI:10.1016/S0960-894X(02)00938-1

Reference yield:

5-methyl-2-nitrobenzoyl chloride (38818-49-4) → N-(4-chlorophenyl)-2-[((3-chlorobenzo[b]thien-2-yl)carbonyl)amino]-5-methylbenzamide (229339-09-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NEt₃ / CH₂Cl₂ / 20 °C

2: SnCl₂*2H₂O / ethyl acetate / Heating

3: pyridine / 0 - 20 °C

With pyridine; triethylamine; tin(ll) chloride; In dichloromethane; ethyl acetate;

DOI:10.1016/S0960-894X(02)00938-1

upstream raw materials:

4-chloro-aniline

2-(3-chloro-benzo[b]thiophen-2-yl)-6-methyl-benzo[d][1,3]oxazin-4-one

3-chlorobenzo[b]thiophen-2-carbonyl chloride

5-methyl-2-nitrobenzoic acid