Technology Process of 1-(3-Amino-1,2-benzisoxazol-5-YL)-6-(2'-{[(3R)-3-hydroxypyrrolidin-1-YL]methyl}biphenyl-4-YL)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-C]pyridin-7-one
There total 24 articles about 1-(3-Amino-1,2-benzisoxazol-5-YL)-6-(2'-{[(3R)-3-hydroxypyrrolidin-1-YL]methyl}biphenyl-4-YL)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-C]pyridin-7-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: phosphorus pentachloride / CHCl3 / Heating
2.1: 140 °C
3.1: DMAP / CH2Cl2
3.2: aq. HCl / diethyl ether
4.1: methanol
5.1: 85 percent / (Ph3P)4Pd; K3PO4 / dioxane
6.1: NaCNBH3
7.1: potassium carbonate / dimethylformamide
With
dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); phosphorus pentachloride; sodium cyanoborohydride; potassium carbonate;
In
1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
5.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.069
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium tert-butoxide
2.1: phosphorus pentachloride / CHCl3 / Heating
3.1: 140 °C
4.1: DMAP / CH2Cl2
4.2: aq. HCl / diethyl ether
5.1: methanol
6.1: 85 percent / (Ph3P)4Pd; K3PO4 / dioxane
7.1: NaCNBH3
8.1: potassium carbonate / dimethylformamide
With
dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); phosphorus pentachloride; potassium tert-butylate; sodium cyanoborohydride; potassium carbonate;
In
1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
6.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.069
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium tert-butoxide
2.1: phosphorus pentachloride / CHCl3 / Heating
3.1: 140 °C
4.1: DMAP / CH2Cl2
4.2: aq. HCl / diethyl ether
5.1: methanol
6.1: 85 percent / (Ph3P)4Pd; K3PO4 / dioxane
7.1: NaCNBH3
8.1: potassium carbonate / dimethylformamide
With
dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); phosphorus pentachloride; potassium tert-butylate; sodium cyanoborohydride; potassium carbonate;
In
1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
6.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.069