Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5-chloro-6',7'-difluoro-2',3',4',9'-tetrahydro-3'-methyl-, (1'R,3'S)-

Base Information

• Chemical Name: Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5-chloro-6',7'-difluoro-2',3',4',9'-tetrahydro-3'-methyl-, (1'R,3'S)-
• CAS No.: 1193314-21-4
• Molecular Formula: C₁₉H₁₆ClN₃O
• Molecular Weight: 337.809
• Mol file: 1193314-21-4.mol

Synonyms:Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5-chloro-2',3',4',9'-tetrahydro-3'-Methyl-, (1'R,3'S)-

Chemical Property of Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5-chloro-6',7'-difluoro-2',3',4',9'-tetrahydro-3'-methyl-, (1'R,3'S)-

Chemical Property:

• PSA: 60.41000
• LogP: 3.96510

Purity/Quality:

99% ^*data from raw suppliers

(1'R,3'S)-5-CHLORO-2',3',4',9'-TETRAHYDRO-3'-METHYL-SPIRO-[3H-INDOLE-3,1'-[1H]PYRIDO-[3,4-B]INDOL]-2(1H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5-chloro-6',7'-difluoro-2',3',4',9'-tetrahydro-3'-methyl-, (1'R,3'S)-

There total 2 articles about Spiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5-chloro-6',7'-difluoro-2',3',4',9'-tetrahydro-3'-methyl-, (1'R,3'S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

5-chloroindole 2,3-dione (17630-76-1) + (+)-alpha-Methyltryptamine (7795-51-9,304-54-1) → (1R,3S)-5'-chloro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one (1193314-21-4)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 110 ℃; for 16h;

Reference yield:

(trans)-5'-chloro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one → (1S,3R)-5'-chloro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one (1193314-22-5) + (1R,3S)-5'-chloro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one (1193314-21-4) + (1S,3S)-5'-chloro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one (1235587-44-6) + (1R,3R)-5'-chloro-3-methyl-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-indol]-2'(1'H)-one (1235587-45-7)

Guidance literature:

With Chiral AD-H column; Resolution of racemate;

DOI:10.1021/jm100410f

upstream raw materials:

5-chloroindole 2,3-dione

(+)-alpha-Methyltryptamine