trans-2-[3-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid

Base Information

Chemical Name:trans-2-[3-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid
CAS No.:243665-18-1
Molecular Formula:C₁₁H₉F₃O₂
Molecular Weight:230.186
Hs Code.:
European Community (EC) Number:831-333-7

Synonyms:243665-18-1;trans-2-[3-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid;(1R,2R)-2-[3-(trifluoromethyl)phenyl]cyclopropane-1-carboxylic Acid;(1R,2R)-2-[3-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid;MFCD30742607;SCHEMBL8979928;IBXCFDILOTYDLI-DTWKUNHWSA-N;AC9746;AC9780;AKOS034818910;EN300-365152;Z2752199417;rac-(1R,2R)-2-[3-(trifluoromethyl)phenyl]cyclopropane-1-carboxylic acid

Suppliers and Price of trans-2-[3-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of trans-2-[3-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:230.05546401
Heavy Atom Count:16
Complexity:287

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C1C(=O)O)C2=CC(=CC=C2)C(F)(F)F
Isomeric SMILES:C1[C@H]([C@@H]1C(=O)O)C2=CC(=CC=C2)C(F)(F)F

Technology Process of trans-2-[3-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid

There total 13 articles about trans-2-[3-(Trifluoromethyl)phenyl]cyclopropanecarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: N-methoxy-N-methyl-trans-2-(3-(trifluoromethyl)phenyl)cyclopropanecarboxamide

: 243665-18-1
trans-2-(3-(trifluoromethyl)phenyl)cyclopropanecarboxylic acid

Guidance literature:: With potassium tert-butylate; In diethyl ether; at 20 ℃; for 16h;
DOI:10.1139/cjc-77-5-6-1123

Reference yield: 84.0%

: 401-81-0
m-trifluoromethylphenyl iodide

: 1759-53-1
cyclopropanecarboxylic acid

: 243665-18-1
(1R,2S)-2-(3-(trifluoromethyl)phenyl)cyclopropane-1-carboxylic acid

Guidance literature:: With (S)-N-(1-(dimethylamino)-3-phenylpropan-2-yl)acetamide; palladium diacetate; sodium carbonate; silver carbonate; at 80 ℃; for 16h; enantioselective reaction; Sealed tube;
DOI:10.1021/jacs.8b03509

Reference yield: 84.0%

: 243665-18-1
(1R,2S)-2-(3-(trifluoromethyl)phenyl)cyclopropane-1-carboxylic acid

Guidance literature:: With (S)-N-(1-(dimethylamino)-3-phenylpropan-2-yl)acetamide; palladium diacetate; sodium carbonate; silver carbonate; at 80 ℃; for 16h; enantioselective reaction; Sealed tube;