1-Phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one

Base Information

Chemical Name:1-Phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one
CAS No.:851337-24-1
Molecular Formula:C25H31N3O
Molecular Weight:389.53
Hs Code.:
Mol file:851337-24-1.mol

Synonyms:1-Phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one;1,3,8-Triazaspiro[4.5]decan-4-one, 1-phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-

Suppliers and Price of 1-Phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-PHENYL-8-[(1S,2S)-2-PHENYLCYCLOHEXYL]-1,3,8-TRIAZASPIRO-[4.5]-DECAN-4-ONE 95.00%
5MG
$ 500.09

Total 5 raw suppliers

Chemical Property of 1-Phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one

Chemical Property:

PSA：39.07000
Density:1.20
LogP:4.42010

Purity/Quality:

99% ^*data from raw suppliers

1-PHENYL-8-[(1S,2S)-2-PHENYLCYCLOHEXYL]-1,3,8-TRIAZASPIRO-[4.5]-DECAN-4-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one

There total 11 articles about 1-Phenyl-8-[(1S,2S)-2-phenylcyclohexyl]-1,3,8-triazaspiro[4.5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1444-65-1
(RS)-2-phenylcyclohexanone

: 851337-24-1
(1S,2S)-1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: TsOH / toluene / Heating

1.2: 70 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 20 °C

2.1: 70 percent / aq. HCl / methanol / Heating

3.1: AcOH / H₂O / 20 °C

4.1: aq. H₂SO₄ / 20 °C

5.1: AcOH / toluene / 48 h / Heating

6.1: separation on chiral-phase HPLC (Chiralpack AD)

With hydrogenchloride; sulfuric acid; toluene-4-sulfonic acid; acetic acid; In methanol; water; toluene; 3.1: Strecker condensation;
DOI:10.1016/j.bmcl.2005.09.075

Reference yield:

: 1444-64-0
2-phenylcyclohexanol

: 851337-24-1
(1S,2S)-1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: aq. Dess-Martin periodinane / CH₂Cl₂ / 20 °C

2.1: TsOH / toluene / Heating

2.2: 70 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 20 °C

3.1: 70 percent / aq. HCl / methanol / Heating

4.1: AcOH / H₂O / 20 °C

5.1: aq. H₂SO₄ / 20 °C

6.1: AcOH / toluene / 48 h / Heating

7.1: separation on chiral-phase HPLC (Chiralpack AD)

With hydrogenchloride; sulfuric acid; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; In methanol; dichloromethane; water; toluene; 4.1: Strecker condensation;
DOI:10.1016/j.bmcl.2005.09.075

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 851337-24-1
(1S,2S)-1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: CuBr*Me₂S / tetrahydrofuran / 0 °C

2.1: aq. Dess-Martin periodinane / CH₂Cl₂ / 20 °C

3.1: TsOH / toluene / Heating

3.2: 70 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 20 °C

4.1: 70 percent / aq. HCl / methanol / Heating

5.1: AcOH / H₂O / 20 °C

6.1: aq. H₂SO₄ / 20 °C

7.1: AcOH / toluene / 48 h / Heating

8.1: separation on chiral-phase HPLC (Chiralpack AD)

With hydrogenchloride; copper(I) bromide dimethylsulfide complex; sulfuric acid; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 5.1: Strecker condensation;
DOI:10.1016/j.bmcl.2005.09.075