Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)

Base Information

Chemical Name:Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)
CAS No.:954138-07-9
Molecular Formula:C₂₄H₃₂N₆O₄
Molecular Weight:468.556
Hs Code.:

Synonyms:3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one;Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl);3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-1H,2H-pyrido[3,4-b]pyrazin-2-one

Suppliers and Price of Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-7-(6-METHOXYPYRIDIN-3-YL)-1-(2-PROPOXYETHYL)PYRIDO[3,4-B]PYRAZIN-2(1H)-ONE 95.00%
10MG
$ 864.70

American Custom Chemicals Corporation
3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-7-(6-METHOXYPYRIDIN-3-YL)-1-(2-PROPOXYETHYL)PYRIDO[3,4-B]PYRAZIN-2(1H)-ONE 95.00%
5MG
$ 808.04

American Custom Chemicals Corporation
3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-7-(6-METHOXYPYRIDIN-3-YL)-1-(2-PROPOXYETHYL)PYRIDO[3,4-B]PYRAZIN-2(1H)-ONE 95.00%
1MG
$ 676.71

Total 2 raw suppliers

Chemical Property of Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)

Chemical Property:

PSA：105.84000
LogP:1.40590

Purity/Quality:: 3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-7-(6-METHOXYPYRIDIN-3-YL)-1-(2-PROPOXYETHYL)PYRIDO[3,4-B]PYRAZIN-2(1H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)

There total 8 articles about Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 954138-53-5
7-chloro-3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one

: 163105-89-3,600726-67-8
2-methoxy-pyridine-5-boronic acid

: 954138-07-9
3-(4-(2-hydroxyethyl)piperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one

Guidance literature:: 7-chloro-3-[4-(2-hydroxyethyl)piperazin-1-yl]-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 20 ℃; for 0.0833333h;

2-methoxy-pyridine-5-boronic acid; With sodium carbonate; In 1,4-dioxane; ethanol; for 16h; Reflux;
DOI:10.1021/acs.jmedchem.6b01666

Reference yield:

: 915307-80-1
6-chloro-N₄-(2-propoxy-ethyl)-pyridine-3,4-diamine

: 954138-07-9
3-(4-(2-hydroxyethyl)piperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

1.2: 8 h / 105 °C

2.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 16 h / 130 °C

3.1: triethylamine / tetrahydrofuran / 4 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.08 h / 20 °C

4.2: 16 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling / 4.2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b01666

Reference yield:

: 1186508-07-5
7-chloro-1-(2-propoxy-ethyl)-1,4-dihydro-pyrido[3,4-b]pyrazine-2,3-dione

: 954138-07-9
3-(4-(2-hydroxyethyl)piperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 16 h / 130 °C

2.1: triethylamine / tetrahydrofuran / 4 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.08 h / 20 °C

3.2: 16 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; 3.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b01666