N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide

Base Information

Chemical Name:N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide
CAS No.:1372263-36-9
Molecular Formula:C₂₂H₃₂ClN₅O₃SSi
Molecular Weight:510.132
Hs Code.:

N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide

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Chemical Property of N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide

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Technology Process of N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide

There total 8 articles about N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1372263-36-9
N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.1: tri-n-butyl(vinyl)tin / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

3.1: osmium(VIII) oxide; 2,6-dimethylpyridine; sodium periodate / 1,4-dioxane; water / 20 °C

4.1: sodium cyanoborohydride; acetic acid / dichloromethane / 3.58 h / 20 °C

4.2: 0.08 h

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; tri-n-butyl(vinyl)tin; sodium hydride; sodium cyanoborohydride; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 1372263-36-9
N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: ammonia; methanol / Ra-Ni / 4 h / 20 °C / 1551.49 Torr

3.1: sodium cyanoborohydride; acetic acid / dichloromethane / 3.58 h / 20 °C

3.2: 0.08 h

With methanol; ammonia; sodium cyanoborohydride; caesium carbonate; acetic acid; Ra-Ni; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 1372263-36-9
N-(2-(((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino)methyl)phenyl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

1.2: 2 h / 0 - 80 °C

1.3: pH 8

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: tri-n-butyl(vinyl)tin / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

4.1: osmium(VIII) oxide; 2,6-dimethylpyridine; sodium periodate / 1,4-dioxane; water / 20 °C

5.1: sodium cyanoborohydride; acetic acid / dichloromethane / 3.58 h / 20 °C

5.2: 0.08 h

With 2,6-dimethylpyridine; hydrogenchloride; sodium periodate; osmium(VIII) oxide; tri-n-butyl(vinyl)tin; sodium hydride; sodium cyanoborohydride; acetic acid; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;