Chemical Property of Temanogrel
Chemical Property:
- PSA：81.34000
- LogP:3.38090
- XLogP3:2.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:8
- Exact Mass:436.21105539
- Heavy Atom Count:32
- Complexity:588
- Purity/Quality:
-
97% *data from raw suppliers
Temanogrel 98.94% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CN1C(=CC=N1)C2=C(C=CC(=C2)NC(=O)C3=CC(=CC=C3)OC)OCCN4CCOCC4
- Recent ClinicalTrials:A Study to Assess the Effect of Oral Temanogrel on Digital Blood Flow in Adult Participants With Raynaud's Phenomenon Secondary to Systemic Sclerosis
- Recent EU Clinical Trials:A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, and Effect on Microvascular Obstruction of Temanogrel in Subjects Undergoing Percutaneous Coronary Intervention.
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Uses
Temanogrel, is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM. Temanogrel also inhibits inositol phosphate accumulation with an IC50 of 5.2 nM. Temanogrel exhibits potent inhibition of serotonin mediated amplification of ADP-stimulated human and dog platelet aggregation (IC50=8.7 and 23.1 nM, respectively
