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Technology Process of PP242

PP242

Base Information
PP242

Synonyms:2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol;2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol;

Suppliers and Price of PP242
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • PP 242
  • 10mg
  • $ 516.00
  • Usbiological
  • PP242
  • 1mg
  • $ 350.00
  • TRC
  • PP242
  • 100mg
  • $ 655.00
  • TRC
  • PP242
  • 50mg
  • $ 350.00
  • TRC
  • PP242
  • 10mg
  • $ 85.00
  • Tocris
  • PP242 ≥98%(HPLC)
  • 5
  • $ 136.00
  • Tocris
  • PP242 ≥98%(HPLC)
  • 25
  • $ 514.00
  • Medical Isotopes, Inc.
  • PP242
  • 50 mg
  • $ 950.00
  • Matrix Scientific
  • 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo-[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol 95%
  • 5g
  • $ 8326.00
  • Matrix Scientific
  • 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo-[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol 95%
  • 1g
  • $ 2776.00
Total 73 raw suppliers
Chemical Property of PP242
Chemical Property:
  • Boiling Point:642.045 °C at 760 mmHg 
  • PKA:9.51±0.40(Predicted) 
  • Flash Point:342.097 °C 
  • PSA：105.64000 
  • Density:1.557 g/cm3 
  • LogP:3.42450 
  • Storage Temp.:-20°C Freezer, Under inert atmosphere 
  • Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated) 
Purity/Quality:

99%, *data from raw suppliers

PP 242 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Description The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin) and regulate different pathways. PP242 is an inhibitor of the active site of mTOR kinase in both mTORC1 and mTORC2 (IC50 = 8 nM). It less effectively inhibits PKCα, PI3-kinase subunit p110γ, JAK2, PKCβI, and PKCβII (IC50 = 49, 102, 110, 198, and 185, respectively). PP242 has been shown to cause the death of certain human and murine leukemia cells more potently than rapamycin and, in vivo, delays leukemia onset and augments the effects of tyrosine kinase inhibitors in suppressing leukemic expansion and extending survival.
  • Uses PP 242 is used in leukemia therapy suppressing mTOR signaling. Dual mTORC1/C2 inhibitor.
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